ID   HSP71_CRYNB             Reviewed;         640 AA.
AC   F5HB71;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Transcriptional coregulator SSA1 {ECO:0000303|PubMed:17040492};
GN   Name=SSA1 {ECO:0000303|PubMed:17040492};
GN   OrderedLocusNames=CNBC4920 {ECO:0000312|EMBL:EAL21790.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643 {ECO:0000312|Proteomes:UP000001435};
RN   [1] {ECO:0000312|Proteomes:UP000001435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A {ECO:0000312|Proteomes:UP000001435};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH HSF1, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17040492; DOI=10.1111/j.1365-2958.2006.05422.x;
RA   Zhang S., Hacham M., Panepinto J., Hu G., Shin S., Zhu X., Williamson P.R.;
RT   "The Hsp70 member, Ssa1, acts as a DNA-binding transcriptional co-activator
RT   of laccase in Cryptococcus neoformans.";
RL   Mol. Microbiol. 62:1090-1101(2006).
CC   -!- FUNCTION: Transcriptional coregulator that functions together with
CC       transcription factor HSF1 (PubMed:17040492). Positively regulates the
CC       expression of laccase LAC1 during glucose starvation (By similarity).
CC       {ECO:0000250|UniProtKB:Q5KKP4, ECO:0000269|PubMed:17040492}.
CC   -!- SUBUNIT: Interacts with transcription factor HSF1 on chromatin.
CC       {ECO:0000269|PubMed:17040492}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5KKP4}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|RuleBase:RU003322}.
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DR   EMBL; AAEY01000015; EAL21790.1; -; Genomic_DNA.
DR   RefSeq; XP_776437.1; XM_771344.1.
DR   AlphaFoldDB; F5HB71; -.
DR   SMR; F5HB71; -.
DR   EnsemblFungi; EAL21790; EAL21790; CNBC4920.
DR   GeneID; 4935157; -.
DR   KEGG; cnb:CNBC4920; -.
DR   VEuPathDB; FungiDB:CNBC4920; -.
DR   HOGENOM; CLU_005965_3_2_1; -.
DR   Proteomes; UP000001435; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Nucleotide-binding; Nucleus; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..640
FT                   /note="Transcriptional coregulator SSA1"
FT                   /id="PRO_0000452017"
FT   REGION          606..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  69353 MW;  C3B5F2AA81F25A98 CRC64;
     MVKAVGIDLG TTYSCVAVWQ NDRVEIIAND QGNRTTPSYV AFNDSERLIG DAAKNQVAMN
     PYNTVFDAKR LIGRKFEDAE VQADMKHWPF KVIDRAGKPA IQVEYRGEEK VFTPEEISSM
     VLIKMKETAE AYLGGTVSKA VVTVPAYFND SQRQATKDAG AIAGLDVLRI INEPTAAAIA
     YGLDKKSEGE KNVLIFDLGG GTFDVSLLTI EEGIFEVKAT AGDTHLGGED FDNRLVNHFV
     QEFKRKNKKD LSSNARALRR LRTACERAKR TLSSAAQTSI EIDSLFDGID FYTSITRARF
     EELCQDLFRS TMDPVEKVLR DSKIDKSSVN EIVLVGGSTR IPKIQKLVSD MFSGREPNRS
     INPDEAVAYG AAVQAAILTG DTSEATQDLL LLDVAPLSMG IETAGGIMTP LIKRNTTVPT
     KKSEVFSTYS DNQPGVLIQV FEGERAKTKD CNLLGKFDLS GIPPAPRGVP QIEVSFDVDA
     NGILNVNAAD KSTGKSSKIT ITNDKGRLSK EEIERMLAEA EKFKAEDEAA AATVQAKNGL
     ESYSYSLKTT LSDNQDKFDA ADHETLSKKV DEVISSLDTM QSASKEEFES LQKELEAVAN
     PIMTKFYGAQ GGAPGGAPGG FPGAGGAPAQ EEGPSVEEVD