ID   HSP71_DROSI             Reviewed;         644 AA.
AC   Q9GSU7; Q9GNG9; Q9GNI6;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-FEB-2004, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Major heat shock 70 kDa protein Ab;
DE            Short=Heat shock protein 70Ab;
DE   AltName: Full=HSP70-87C1;
GN   Name=Hsp70Ab;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240 {ECO:0000312|EMBL:AAG24840.1};
RN   [1] {ECO:0000312|EMBL:AAG24840.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSR 1 {ECO:0000312|EMBL:AAG24838.1},
RC   DSR 2 {ECO:0000312|EMBL:AAG24839.1}, DSR 3 {ECO:0000312|EMBL:AAG24840.1},
RC   and DSR 4 {ECO:0000312|EMBL:AAG24841.1};
RX   PubMed=11965431; DOI=10.1007/s00239-001-0044-7;
RA   Bettencourt B.R., Feder M.E.;
RT   "Rapid concerted evolution via gene conversion at the Drosophila hsp70
RT   genes.";
RL   J. Mol. Evol. 54:569-586(2002).
CC   -!- INDUCTION: Heat shock induces the synthesis of seven proteins at five
CC       otherwise inactive sites in the polytene chromosomes of fruit fly
CC       larvae. Two separate sites, producing two and three copies,
CC       respectively, code for the 70 kDa protein. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Most strains have three copies of the gene coding for
CC       this protein at chromosome locus 87C1; two tandemly repeated Hsp70
CC       genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba).
CC       Some strains, including that sequenced in the Drosophila genome project
CC       have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and
CC       Hsp70Bc). {ECO:0000250|UniProtKB:P02825}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|RuleBase:RU003322, ECO:0000305}.
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DR   EMBL; AF295967; AAG24838.1; -; Genomic_DNA.
DR   EMBL; AF295968; AAG24839.1; -; Genomic_DNA.
DR   EMBL; AF295969; AAG24840.1; -; Genomic_DNA.
DR   EMBL; AF295970; AAG24841.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9GSU7; -.
DR   SMR; Q9GSU7; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0009408; P:response to heat; ISS:UniProtKB.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..644
FT                   /note="Major heat shock 70 kDa protein Ab"
FT                   /id="PRO_0000078331"
FT   REGION          610..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         22
FT                   /note="E -> K (in strain: DSR 3 and DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         84
FT                   /note="I -> M (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         95
FT                   /note="G -> C (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         122
FT                   /note="V -> A (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         306
FT                   /note="D -> N (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         320
FT                   /note="N -> T (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         383
FT                   /note="T -> S (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         550..552
FT                   /note="AVD -> SVE (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         593
FT                   /note="L -> M (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         617
FT                   /note="Missing (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
SQ   SEQUENCE   644 AA;  70304 MW;  32C123BBA1BCB194 CRC64;
     MPAIGIDLGT TYSCVGVYQH GEVEIIANDQ GNRTTPSYVA FTDSERLIGD PAKNQVAMNP
     RNTVFDAKRL IGRKYDDPKI AEDIKHWPFK VVSDGGKPKI GVEYKGESKR FAPEEISSMV
     LVKMKETAEA YLGESITDAV ITVPAYFNDS QRQATKDAGH IAGLNVLRII NEPTAAALAY
     GLDKNLKGER NVLIFDLGGG TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA
     EEFKRKYKKD LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
     EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE FFHGKNLNLS
     INPDEAVAYG AAVQAAILSG DQTGKIQDVL LVDVAPLSLG IETAGGVMTK LIERNCRIPC
     KQTKTFSTYS DNQPGVSIQV YEGERAMTKD NNALGTFDLS GIPPAPRGVP QIEVTFDLDA
     NGILNVSAKE MSTGKAKNIT IKNDKGRLSQ AEIDRMVNEA EKYADEDEKQ RQRITSRNAL
     ESYVFNVKQA VDQAPAGKLD EADKNSVLDK CNDTIRWLDS NTTAEKEEFD HKLEELTRHC
     SPIMTKMHQQ GAGAGAGAGG PGANCGQQAG GFGGYSGPTV EEVD