ID   HSP72_DROSI             Reviewed;         643 AA.
AC   Q9GSU4; Q9GNI6; Q9GSU5; Q9GSU6;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-FEB-2004, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Major heat shock 70 kDa protein Ba;
DE            Short=Heat shock protein 70Ba;
DE   AltName: Full=HSP70-87C1;
GN   Name=Hsp70Ba;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240 {ECO:0000312|EMBL:AAG24845.1};
RN   [1] {ECO:0000312|EMBL:AAG24845.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSR 1 {ECO:0000312|EMBL:AAG24842.1},
RC   DSR 2 {ECO:0000312|EMBL:AAG24843.1}, DSR 3 {ECO:0000312|EMBL:AAG24844.1},
RC   and DSR 4 {ECO:0000312|EMBL:AAG24845.1};
RX   PubMed=11965431; DOI=10.1007/s00239-001-0044-7;
RA   Bettencourt B.R., Feder M.E.;
RT   "Rapid concerted evolution via gene conversion at the Drosophila hsp70
RT   genes.";
RL   J. Mol. Evol. 54:569-586(2002).
CC   -!- INDUCTION: Heat shock induces the synthesis of seven proteins at five
CC       otherwise inactive sites in the polytene chromosomes of fruit fly
CC       larvae. Two separate sites, producing two and three copies,
CC       respectively, code for the 70 kDa protein. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Most strains have three copies of the gene coding for
CC       this protein at chromosome locus 87C1; two tandemly repeated Hsp70
CC       genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba).
CC       Some strains, including that sequenced in the Drosophila genome project
CC       have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and
CC       Hsp70Bc). {ECO:0000250|UniProtKB:P02824}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|RuleBase:RU003322, ECO:0000305}.
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DR   EMBL; AF295971; AAG24842.1; -; Genomic_DNA.
DR   EMBL; AF295972; AAG24843.1; -; Genomic_DNA.
DR   EMBL; AF295973; AAG24844.1; -; Genomic_DNA.
DR   EMBL; AF295974; AAG24845.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9GSU4; -.
DR   SMR; Q9GSU4; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..643
FT                   /note="Major heat shock 70 kDa protein Ba"
FT                   /id="PRO_0000078336"
FT   REGION          611..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         25
FT                   /note="I -> T (in strain: DSR 2)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         208
FT                   /note="T -> A (in strain: DSR 1)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         286
FT                   /note="F -> L (in strain: DSR 3)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         306
FT                   /note="D -> N (in strain: DSR 4)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         358
FT                   /note="N -> S (in strain: DSR 1)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         483
FT                   /note="I -> T (in strain: DSR 2)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
FT   VARIANT         617
FT                   /note="A -> T (in strain: DSR 3)"
FT                   /evidence="ECO:0000269|PubMed:11965431"
SQ   SEQUENCE   643 AA;  70303 MW;  29237D6AB8C96C16 CRC64;
     MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD PAKNQVAMNP
     RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDCGKPKI GVEYKGESKR FAPEEISSMV
     LAKMKETAEA YLGESITDAV ITVPAYFNDS QRQATKDAGH IAGLNVLRII NEPTAAALAY
     GLDKNLKGER NVLIFDLGGG TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA
     EEFKRKYKKD LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
     EELCADLFRN TLQPVEKALT DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE FFHGKNLNLS
     INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG IETAGGVMTK LIERNCRIPC
     KQTKTFSTYS DNQPGVSIQV YEGERAMTKD NNALGTFDLS GIPPAPRGVP QIEVTFDLDA
     NGILNVSAKE MSTGKAKNIT IKNDKGRLSQ AEIDRMVNEA EKYADEDEKQ RQRITSRNAL
     ESYVFNVKQS VEQAPAGKLD EADKNSVLDK CNDTIRWLDS NTTAEKEEFD HKMEELTRHC
     SPIMTKMHQQ GAGAGAAGGP GANCGQQAGG FGGYSGPTVE EVD