ID   HSP72_PARBA             Reviewed;         654 AA.
AC   Q96W30; C1HB62;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Heat shock 70 kDa protein 2;
GN   Name=HSP70-2; ORFNames=PAAG_08003;
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16320493; DOI=10.1080/13693780400029478;
RA   Bisio L.C., Silva S.P., Pereira I.S., Xavier M.A.S., Venancio E.J.,
RA   Puccia R., de Almeida Soares C.M., Felipe M.S.S.;
RT   "A new Paracoccidioides brasiliensis 70-kDa heat shock protein reacts with
RT   sera from paracoccidioidomycosis patients.";
RL   Med. Mycol. 43:495-503(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AF386787; AAK66771.1; -; mRNA.
DR   EMBL; KN294019; EEH37585.1; -; Genomic_DNA.
DR   RefSeq; XP_002790117.1; XM_002790071.2.
DR   AlphaFoldDB; Q96W30; -.
DR   SMR; Q96W30; -.
DR   STRING; 502779.Q96W30; -.
DR   PRIDE; Q96W30; -.
DR   EnsemblFungi; EEH37585; EEH37585; PAAG_08003.
DR   GeneID; 9093358; -.
DR   KEGG; pbl:PAAG_08003; -.
DR   VEuPathDB; FungiDB:PAAG_08003; -.
DR   eggNOG; KOG0101; Eukaryota.
DR   HOGENOM; CLU_005965_3_2_1; -.
DR   OMA; KANPIMM; -.
DR   OrthoDB; 288077at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblFungi.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:EnsemblFungi.
DR   GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IEA:EnsemblFungi.
DR   GO; GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IEA:EnsemblFungi.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome;
KW   Stress response.
FT   CHAIN           1..654
FT                   /note="Heat shock 70 kDa protein 2"
FT                   /id="PRO_0000382652"
FT   REGION          612..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        213
FT                   /note="G -> D (in Ref. 1; AAK66771)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   654 AA;  70792 MW;  8F1D81CDF21B45A6 CRC64;
     MAPAIGIDLG TTYSCVGIFR DDRIEIIAND QGNRTTPSFV AFTDTERLIG DAAKNQVAMN
     PSNTVFDAKR LIGRKFADPE VQSDMKHFPF KVIDKAGKPV ISVEFKGEEK QFTPEEISSM
     VLTKMRETAE SYLGGTVNNA VVTVPAYFND SQRQATKDAG LIAGLNVLRI INEPTAAAIA
     YGLDKKAEGE RNVLIFDLGG GTFDVSLLTI EEGIFEVKST AGDTHLGGED FDNRLVNHFV
     NEFKRKHKKD LSSNARALRR LRTACERAKR TLSSAAQTSI EIDSLYEGID FYTSITRARF
     EELCQDLFRS TMDPVERVLR DAKIDKSSVH EIVLVGGSTR IPRIQKLVSD FFNGKEPNKS
     INPDEAVAYG AAVQAAILSG DTTSKSTNEI LLLDVAPLSV GIETAGGVMT PLIKRNTTIP
     TKKSETFSTF ADNQPGVLIQ VFEGERARTK DNNLLGKFEL TGIPPAPRGV PQIEVTFDVD
     ANGIMNVSAL EKGTGKTNKI VITNDKGRLS KEEIERMLAE AEKYKAEDEA EASRISAKNG
     LESYAYSLRN TISDSKVDEK LDASDKEKLK TEIDKTVSWL DENQTATKEE FEAQQKELES
     VANPIMMKFY GAGGEGGAPG AGFPGAGGPG GFPGAGAGGA HSGGDDGPTV EEVD