ID   HSP72_PICAN             Reviewed;         643 AA.
AC   P53623; P53422;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Heat shock protein 70 2;
GN   Name=HSA2;
OS   Pichia angusta (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=870730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL
RC   Y-5445;
RA   Diesel A., Roggenkamp R.O.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; U49932; AAB63968.1; -; Genomic_DNA.
DR   AlphaFoldDB; P53623; -.
DR   SMR; P53623; -.
DR   PRIDE; P53623; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   Acetylation; ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding;
KW   Stress response.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..643
FT                   /note="Heat shock protein 70 2"
FT                   /id="PRO_0000078377"
FT   REGION          609..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   643 AA;  70073 MW;  205AE0C965AEFCD6 CRC64;
     MSKAVGIDGG TTYSCVAHFA NDRVEIIAND QGNRTTPSFV AFTDTERLSG DAAKNQAAMN
     PANTVFDAKR LIGRKFDDPE VQGDIKHFPF KVVDKSGKPQ IQVEFKGETK VFTPEEISSM
     VLTKMKETAE SFLGTTVKDA VITVPAYFND SQRQATKDAG LIAGLNVMRI INEPTAAAIA
     YGLDKKSQGE QNVLIFDLGG GTFDVSLLSI EDGIFEVKAT AGDTHLGGED FDNRLVNHFI
     NEFKRKNKKD ICGNQRALRR LRTACERAKT TLSSSAQTSL EIDSLYEGID FYTSITRARF
     EELCQDLFRS TLDPVEKVLK DAKLDKSQVN EIVLVGGSTR IPKVQKLVSD FFNGKEPNKS
     INPDEAVAYG AAVQAAILTG DTSSKTQDLL LLDVAPLSLG IETAGGVMTK LIPRNTTIPT
     KKSEIFSTYS DNQPGVLIQV YEGERARTKD NNLLGKFELS GIPPAPRGVP QIEVTFDIDA
     NGILNVSAVE KGTGKSEKIT ITNDKGRLSQ EEIERMVSEA EKYKEEDEKE AKRIAAKNGL
     ESYAYSLKQT TSEKQFEEKV EASKREAFTK ACDDTIAWLD ENQTATAEEY DDKRKELEQA
     GNEVLKDLYA EGGVPGGAPG GFPGAGGAPS TEETQGPTVE EVD