ID   HSP74_LEIMA             Reviewed;         228 AA.
AC   P12077;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Heat shock 70-related protein 4;
DE   Flags: Fragment;
GN   Name=HSP70.4;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MHOM/IL/8/Friedlin;
RX   PubMed=2762121; DOI=10.1093/nar/17.13.5081;
RA   Searle S., Campos A.J.R., Coulson R.M.R., Spithill T.W., Smith D.F.;
RT   "A family of heat shock protein 70-related genes are expressed in the
RT   promastigotes of Leishmania major.";
RL   Nucleic Acids Res. 17:5081-5095(1989).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X14575; CAA32714.1; -; Genomic_DNA.
DR   PIR; S05439; S05439.
DR   AlphaFoldDB; P12077; -.
DR   SMR; P12077; -.
DR   PRIDE; P12077; -.
DR   VEuPathDB; TriTrypDB:LmjF.26.1240; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_260018100; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_260016500; -.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..>228
FT                   /note="Heat shock 70-related protein 4"
FT                   /id="PRO_0000078307"
FT   REGION          57..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         228
SQ   SEQUENCE   228 AA;  24812 MW;  FC04C6DE7808330D CRC64;
     MSSTKHRIDL GTTYSCVGVF KNEQVDIIAN DQGNRTTPSY VAFTETERLI GDARRTRWHE
     PPGNTVFDEA HDRPQVRRPD LQSDMKHWPF KVIVKDGKPV ISVEYQNQTK TFSRGDLGYG
     AAENEGDGGG YLGTTVKDAV ITVPAYFNDS QRQATKDAGS IAGLNVLRII NEPTAAAIAY
     GMDRKGDKGE KNVLIFDLGG GTFDVTLLTI ESGVFEVKAT AGDTHLGG