ID   HSP74_TRYBB             Reviewed;         661 AA.
AC   P11145;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Heat shock 70 kDa protein 4;
DE            Short=HSP70-4;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3796613; DOI=10.1128/mcb.6.12.4657-4666.1986;
RA   Glass D.J., Polvere R.I., van der Ploeg L.H.T.;
RT   "Conserved sequences and transcription of the hsp70 gene family in
RT   Trypanosoma brucei.";
RL   Mol. Cell. Biol. 6:4657-4666(1986).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; M14697; AAA30204.1; -; mRNA.
DR   PIR; A25398; A25398.
DR   PRIDE; P11145; -.
DR   GO; GO:0020015; C:glycosome; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IDA:GeneDB.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0009408; P:response to heat; IEP:GeneDB.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..661
FT                   /note="Heat shock 70 kDa protein 4"
FT                   /id="PRO_0000078321"
FT   REGION          617..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  71436 MW;  F9F927003E595A13 CRC64;
     MTYEGAIGID LGTTYSCVGV WQNERVEIIA NDQGNRTTPS YVAFTDSERL IGDAAKNQVA
     MNPTNTVFDA KRLIGRKFSD SVVQSDMKHW PFKVVTKGDD KPVIQVQFRG ETKTFNPEEI
     SSMVLLKMKE VAESYLGKQV AKAVVTVPAY FNDSQRQATK DAGTIAGLEV LRIINEPTAA
     AIAYGLDKAD EGKERNVLIF DLGGGTFDVT LLTIDGGIFE VKATNGDTHL GGEDFDNRLV
     AHFTEEFKRK NKGKDLSSNL RALRRLRTAC ERAKRTLSSA AQATIEIDAL FENIDFQATI
     TRARFEELCG DLFRGTLQPV ERVLQDAKMD KRAVHDVVLV GGSTRIPKVM QLVSDFFGGK
     ELNKSINPDE AVXYGAAVQA FILTGGKSKQ TEGLLLLDVA PLTLGIETAG GVMTALIKRN
     TTIPTKKSQI FSTYSDNQPG VHIQVFEGER TMTKDCHLLG TFDLSGIPPA PRGVPQIEVT
     FDLDANGILS VSAEEKGTGK RNQIVITNDK GRLSKADIER MVSDAAKYEA EDKAHVXXID
     AKNGLENYAF SMKNTINDPN VAGKLDDADK NAVTTAVEEA LRWLNDNQEA SLEEYNHRQK
     ELEGVCAPIL SKMYQGMGGG DGPGGMPEGM PGGMPGGMPG GMGGGMGGAA ASSGPKVEEV
     D