HSP77_HUMAN
ID HSP77_HUMAN Reviewed; 367 AA.
AC P48741; P19790;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Putative heat shock 70 kDa protein 7;
DE AltName: Full=Heat shock 70 kDa protein B;
GN Name=HSPA7; Synonyms=HSP70B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.
RX PubMed=3927293; DOI=10.1073/pnas.82.15.4949;
RA Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D.;
RT "Isolation and functional analysis of a human 70,000-dalton heat shock
RT protein gene segment.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985).
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AL451067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M11236; AAA52696.1; -; Genomic_DNA.
DR PIR; A25773; A25773.
DR AlphaFoldDB; P48741; -.
DR SMR; P48741; -.
DR IntAct; P48741; 46.
DR GlyConnect; 1695; 1 N-Linked glycan (1 site).
DR iPTMnet; P48741; -.
DR PhosphoSitePlus; P48741; -.
DR SwissPalm; P48741; -.
DR BioMuta; HGNC:5240; -.
DR EPD; P48741; -.
DR jPOST; P48741; -.
DR MassIVE; P48741; -.
DR MaxQB; P48741; -.
DR PeptideAtlas; P48741; -.
DR PRIDE; P48741; -.
DR ProteomicsDB; 55940; -.
DR GeneCards; HSPA7; -.
DR HGNC; HGNC:5240; HSPA7.
DR MIM; 140556; gene.
DR neXtProt; NX_P48741; -.
DR InParanoid; P48741; -.
DR PhylomeDB; P48741; -.
DR PathwayCommons; P48741; -.
DR Reactome; R-HSA-3371453; Regulation of HSF1-mediated heat shock response.
DR SignaLink; P48741; -.
DR Pharos; P48741; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P48741; protein.
DR GO; GO:0072562; C:blood microparticle; HDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375; PTHR19375; 1.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
PE 5: Uncertain;
KW ATP-binding; Nucleotide-binding; Reference proteome; Stress response.
FT CHAIN 1..367
FT /note="Putative heat shock 70 kDa protein 7"
FT /id="PRO_0000078267"
FT CONFLICT 59
FT /note="S -> N (in Ref. 2; AAA52696)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="Q -> K (in Ref. 2; AAA52696)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="E -> G (in Ref. 2; AAA52696)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="S -> T (in Ref. 2; AAA52696)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="G -> R (in Ref. 2; AAA52696)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="S -> T (in Ref. 2; AAA52696)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 367 AA; 40244 MW; 060DFA210A29A5D4 CRC64;
MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ
AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG GKPKVRVCYR GEDKTFYPEE
ISSMVLSKMK ETAEAYLGQP VKHAVITVPT YFSNSQRQAT KDAGAIAGLK VLPIINEATA
AAIAYGLDRR GAGKRNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV
NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE VAAGLLQRQG
AEQEHQP
