ID   HSP7A_ENCCU             Reviewed;         683 AA.
AC   Q8SWH2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Heat shock protein ECU02_0100;
GN   OrderedLocusNames=ECU02_0100;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GB-M1;
RX   PubMed=20003517; DOI=10.1186/1471-2164-10-607;
RA   Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P.,
RA   Cornman R.S., Evans J.D., Delbac F., Peyret P.;
RT   "Identification of transcriptional signals in Encephalitozoon cuniculi
RT   widespread among Microsporidia phylum: support for accurate structural
RT   genome annotation.";
RL   BMC Genomics 10:607-607(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AL590442; CAD25041.2; -; Genomic_DNA.
DR   RefSeq; NP_584537.1; NM_001040726.1.
DR   AlphaFoldDB; Q8SWH2; -.
DR   SMR; Q8SWH2; -.
DR   STRING; 284813.Q8SWH2; -.
DR   GeneID; 858527; -.
DR   KEGG; ecu:ECU02_0100; -.
DR   VEuPathDB; MicrosporidiaDB:ECU02_0100; -.
DR   HOGENOM; CLU_005965_2_1_1; -.
DR   InParanoid; Q8SWH2; -.
DR   OrthoDB; 1215420at2759; -.
DR   Proteomes; UP000000819; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00014; ER_TARGET; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Protein biosynthesis;
KW   Reference proteome; Stress response.
FT   CHAIN           1..683
FT                   /note="Heat shock protein ECU02_0100"
FT                   /id="PRO_0000383324"
SQ   SEQUENCE   683 AA;  75802 MW;  7574B929D04CF561 CRC64;
     MLVRGLLSAV ATIFCGAPKD TDLRESVAVG IDLGTTYSCI SVYSPSSKDT RFVLSPGGEE
     TYPSVVYFKK LPEGDGKKSK YEAVAGWPGL QMYNAEGNAN TYFYAFKRGM GIEDLANIDK
     KVEEIKRNAS VPIFVESVGG KKRVAYKIQE AMQDGYESVT PEELSSHVLR MLKDQIVKDY
     KIQGLTITVP AYFDVNQVAA TIKAAEMAGF PTPIIWKEPS AAAFAHTYDL IRKGITTKEE
     VDDMNICVFD LGGGTFDVSI VESSGGFMMV PSYGGNNFLG GENVNDNLTK YFADYIKSST
     GFDVMENQNV KLRLRNVVED MKRDLCDEVR KSPGRKANPS ISKSFIYDGE KSIVLELTNE
     KFNELNADFY SRIRKTMDSL LSGDGKDNKG YDKSLINRVL LVGGSTRIPK VIDIVEEIFG
     ANKIYSEGVN ADTIVARGAA LYTANSLNLL NESEQIVTAD SVPLSLGICT EEDHFEAIIS
     KGALLPATGT KEFTTAQDNQ TKVRIRVAQG GLESFKDNIY IGDIELDLPG NQPRGVPRIA
     VTLEIDTHGK IYVKAVDLQN NKEASSYFSS VVANMTSEEI ERFEERVHGE ENQELVKKRE
     VVRKLEQAIS QAESPKFAEV IPENIKKDAL EYVQKTRLWL EKHKEIAPRI HIEEKLQEFD
     NGMKEFLSSA KSGEEKEIGR EEL