HSP7B_DROME
ID HSP7B_DROME Reviewed; 633 AA.
AC P11146; Q5U0V1; Q9VFZ5;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Heat shock 70 kDa protein cognate 2;
DE AltName: Full=Heat shock 70 kDa protein 87D;
GN Name=Hsc70-2; Synonyms=Hsc2; ORFNames=CG7756;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68.
RX PubMed=6311649; DOI=10.1016/0012-1606(83)90291-9;
RA Craig E.A., Ingolia T.D., Manseau L.J.;
RT "Expression of Drosophila heat-shock cognate genes during heat shock and
RT development.";
RL Dev. Biol. 99:418-426(1983).
CC -!- DEVELOPMENTAL STAGE: Heat shock cognate proteins are expressed
CC constitutively during normal development.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54899.1; -; Genomic_DNA.
DR EMBL; BT016141; AAV37026.1; -; mRNA.
DR EMBL; K01297; AAA28630.1; -; Genomic_DNA.
DR EMBL; K01296; AAA28630.1; JOINED; Genomic_DNA.
DR RefSeq; NP_524339.1; NM_079615.4.
DR PDB; 2B26; X-ray; 3.20 A; D=626-632.
DR PDBsum; 2B26; -.
DR AlphaFoldDB; P11146; -.
DR SMR; P11146; -.
DR BioGRID; 66696; 10.
DR IntAct; P11146; 1.
DR STRING; 7227.FBpp0082175; -.
DR PaxDb; P11146; -.
DR PRIDE; P11146; -.
DR DNASU; 41609; -.
DR EnsemblMetazoa; FBtr0082707; FBpp0082175; FBgn0001217.
DR GeneID; 41609; -.
DR KEGG; dme:Dmel_CG7756; -.
DR CTD; 41609; -.
DR FlyBase; FBgn0001217; Hsc70-2.
DR VEuPathDB; VectorBase:FBgn0001217; -.
DR eggNOG; KOG0101; Eukaryota.
DR GeneTree; ENSGT00940000154813; -.
DR HOGENOM; CLU_005965_3_0_1; -.
DR InParanoid; P11146; -.
DR OMA; IYGCKQA; -.
DR OrthoDB; 288077at2759; -.
DR PhylomeDB; P11146; -.
DR Reactome; R-DME-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DME-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-DME-3371571; HSF1-dependent transactivation.
DR BioGRID-ORCS; 41609; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Hsc70-2; fly.
DR EvolutionaryTrace; P11146; -.
DR GenomeRNAi; 41609; -.
DR PRO; PR:P11146; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0001217; Expressed in testis and 14 other tissues.
DR Genevisible; P11146; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 2.60.34.10; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375; PTHR19375; 1.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF100934; SSF100934; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Nucleotide-binding; Reference proteome;
KW Stress response.
FT CHAIN 1..633
FT /note="Heat shock 70 kDa protein cognate 2"
FT /id="PRO_0000078339"
FT REGION 610..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 69722 MW; 851D3FBEDB227F08 CRC64;
MGKIPAIGID LGTTYSCVGV WQNSKVEIIA NDQGNRTTPS YVAFNETERL IGDPAKNQVA
MNAKNTVFDA KRLIGRKFDD KKIQEDLKLW PFKVINEKGK PKIEVEFKGE RKRFAPEEIS
SMVLTKMREI AEVYLGGKVK DAVVTVPAYF NDSQRQATKD AGSIAGLNVL RIINEPTAAA
LAYGLDKNLK GERNVLIFDL GGGTFDVSVL SIDEGSLFEV KATAGDTHLG GEDFDNRLVN
HFAEEFKRKH KSDIKGNARA LRRLRTACER AKRTLSSSTE ASLEIDALHE GIDFYSKISR
ARFEELNMDL FRSTMQPVER ALSDAKMDKK AIHDVVLVGG STRIPKIQKL LQDLFGGKQL
NLSINPDEAV AYGAAVQAAI LTGVGSSQIQ DLLLVDVAPL SLGIETAGGV MTNLVERNAR
IPCKQQQIFT TYSDNQNAVT IQVYEGERAM TKDNNLLGTF NLTGIPPAPR GVPQIEVAFD
LNADGILNVN AKDNSTGKSE KITISNDKGR LSKAEIDRML SEAEKYKVED DRQRERVQSK
NNLEAYIYAC RQAVDDAPSG VLSETERSKV RDKCSSEASW LDKNSLAEKE EFESHLKECQ
RICTPIMSKI HGGKKGKSSM GKGSHPTVEE VDG
