ID   HSP7C_TRYBB             Reviewed;         676 AA.
AC   P20030;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Heat shock cognate HSP70 protein;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2398917; DOI=10.1016/0166-6851(90)90184-n;
RA   Lee M.G.-S., Polvere R.I., van der Ploeg L.H.T.;
RT   "Evidence for segmental gene conversion between a cognate hsp 70 gene and
RT   the temperature-sensitively transcribed hsp70 genes of Trypanosoma
RT   brucei.";
RL   Mol. Biochem. Parasitol. 41:213-220(1990).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; M32139; AAA30208.1; -; Genomic_DNA.
DR   PIR; A45515; A45515.
DR   AlphaFoldDB; P20030; -.
DR   SMR; P20030; -.
DR   PRIDE; P20030; -.
DR   GO; GO:0005654; C:nucleoplasm; IDA:GeneDB.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..676
FT                   /note="Heat shock cognate HSP70 protein"
FT                   /id="PRO_0000078322"
FT   REGION          613..676
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..676
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  73695 MW;  AD67B783124B785E CRC64;
     MTYEGAIGID LGTTYSCVGV WQNERVEIIA NDQGNRTTPS YVAFVNNEVL VGDAAKSHAA
     RGSNGVIFDA KRLIGRKFSD SVVQSDMKHW PFKVEEGEKG GAVMRVEHLG EGMLLQPEQI
     SARVLAYLKS CAESYLGKQV AKAVVTVPAY FNDSQRQATK DAGTIAGLEV LRIINEPTAA
     AIAYGLDKAD EGKERNVLVF DFGGGTFDVS IISVSGGVFE VKATNGDTHL GGEDVDAALL
     EHALADIRNR YGIEQGSLSQ KMLSKLRSRC EEVKRVLSHS TVGEIALDGL LPDGEEYVLK
     LTRARLEELC TKIFARCLSV VQRALKDASM KVEDIEDVVL VGGSSRIPAV QAQLRELFRG
     KQLCSSVHPD EAVAYGAAWQ AHVLSGGYGE SSRTAGIVLL DVVPLSIGVE VDDGKFDVII
     RRNTTIPYLA TKEYSTVDDN QSEVEIQVFE GERPLTRHNH RLGSFVLDGI TPAKHGEPTI
     TVTFSVDADG ILTVTAAEEL GSVTKTLVVE NSERLTSEEV QKMIEVAQKF ALTDATALAR
     MEATERLTQW FDRLEAVMET VPQPYSEKLQ KRIAFLPHGK EWVGTQLHTY TDAASIEAKV
     AKIERLAKRA LKSARREGKD GWAPGNEDNG SGDDNDGDDN SDEEDELQRG RGVTEGSGRS
     PIRKRDRIEA INANTE