ID   HSP7D_MANSE             Reviewed;         652 AA.
AC   Q9U639;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Heat shock 70 kDa protein cognate 4;
DE            Short=Hsc 70-4;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Prothoracic gland;
RX   PubMed=10844250; DOI=10.1016/s0965-1748(00)00031-x;
RA   Rybczynski R., Gilbert L.I.;
RT   "cDNA cloning and expression of a hormone-regulated heat shock protein (hsc
RT   70) from the prothoracic gland of Manduca sexta.";
RL   Insect Biochem. Mol. Biol. 30:579-589(2000).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Heat shock cognate proteins are expressed
CC       constitutively during normal development.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AF194819; AAF09496.1; -; mRNA.
DR   AlphaFoldDB; Q9U639; -.
DR   SMR; Q9U639; -.
DR   PRIDE; Q9U639; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Nucleus; Stress response.
FT   CHAIN           1..652
FT                   /note="Heat shock 70 kDa protein cognate 4"
FT                   /id="PRO_0000078341"
FT   REGION          624..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  71432 MW;  F5DBFEA4FEF76E3E CRC64;
     MAKAPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTDRL IGDAAKNQVA
     MNPNNTIFDA KRLIGRKFED ATVQADMKHW PFEVVSDGGK PKIKVAYKGE DKTFFPEEVS
     SMVLTKMKET AEAYLGKTVQ NAVITVPAYF NDSQRQATKD AGTISGLNVL RIINEPTAAA
     IAYGLDKKGS GERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH
     FVQEFKRKYK KDLTTNKRAL RRLRTACERA KRTLSSSTQA SIEIDSLFEG IDFYTSITRA
     RFEELNADLF RSTMEPVEKS LRDAKMDKSQ IHDIVLVGGS TRIPKVQKLL QDFFNGKELN
     KSINPDEAVA YGAAVQAAIL HGDKSEEVQD LLLLDVTPLS LGIETAGGVM TTLIKRNTTI
     PTKQTQTFTT YSDNQPGVLI QVFEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI
     DANGILNVSA VEKSTNKENK ITITNDKGRL SKEEIERMVN EAEKYRNEDE KQKETIQAKN
     ALESYCFNMK STMEDEKLKD KISDSDKQTI LDKCNDTIKW LDSNQLADKE EYEHKQKELE
     GICNPIITKL YQGAGGMPGG MPGGMPGFPG GAPGAGGAAP GGGAGPTIEE VD