ID   HSP7E_RAT               Reviewed;         509 AA.
AC   Q6AYB4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Heat shock 70 kDa protein 14;
GN   Name=Hspa14;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the ribosome-associated complex (RAC), a complex
CC       involved in folding or maintaining nascent polypeptides in a folding-
CC       competent state. In the RAC complex, binds to the nascent polypeptide
CC       chain, while DNAJC2 stimulates its ATPase activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of ribosome-associated complex (RAC), a heterodimer
CC       composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type
CC       chaperone DNAJC2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; BC079118; AAH79118.1; -; mRNA.
DR   RefSeq; NP_001004257.1; NM_001004257.1.
DR   AlphaFoldDB; Q6AYB4; -.
DR   SMR; Q6AYB4; -.
DR   CORUM; Q6AYB4; -.
DR   STRING; 10116.ENSRNOP00000020854; -.
DR   jPOST; Q6AYB4; -.
DR   PaxDb; Q6AYB4; -.
DR   PRIDE; Q6AYB4; -.
DR   Ensembl; ENSRNOT00000020854; ENSRNOP00000020854; ENSRNOG00000015212.
DR   GeneID; 307133; -.
DR   KEGG; rno:307133; -.
DR   UCSC; RGD:1303296; rat.
DR   CTD; 51182; -.
DR   RGD; 1303296; Hspa14.
DR   eggNOG; KOG0101; Eukaryota.
DR   GeneTree; ENSGT00940000156380; -.
DR   HOGENOM; CLU_005965_0_3_1; -.
DR   InParanoid; Q6AYB4; -.
DR   OMA; YIKESKC; -.
DR   OrthoDB; 646813at2759; -.
DR   PhylomeDB; Q6AYB4; -.
DR   TreeFam; TF105045; -.
DR   Reactome; R-RNO-3371453; Regulation of HSF1-mediated heat shock response.
DR   PRO; PR:Q6AYB4; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000015212; Expressed in thymus and 19 other tissues.
DR   Genevisible; Q6AYB4; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005840; C:ribosome; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd10238; HSPA14-like_NBD; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR042049; HSPA14_NBD.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..509
FT                   /note="Heat shock 70 kDa protein 14"
FT                   /id="PRO_0000289948"
SQ   SEQUENCE   509 AA;  54463 MW;  124B694373C553AA CRC64;
     MAAIGVHLGC TSACVAVYKD GRADVVANDA GDRVTPAVVA YSEREQVVGL AAKQSRIRNI
     SSTVVKVKQI LGRSTADPQA QKYISESKCL VIEKNGKLQY EIDTGEETKL VSPEDVARLI
     FSKMKETAHS VLGSDANDVV VTVPFDFGEK QKSALGEAAG AAGFNVLRLI HEPSAALLAY
     GIGQDCPTGK SNVLVFKLGG TSLSLSIMEV NSGMYRVLST NTSDNIGGVH FTDSLAQYLA
     SEFQRLFKHD VRGSARAMMK LMNSAEVAKH SLSTLGSANC FVDSLYEGQD FDCNVSRARF
     ELLCSPLFNK CIEAVRALLQ QSGFTADDIN KVVLCGGSSR IPRLQQLIKD LFPAGDLLNS
     IPPDEVIPIG AAIEAGILVG KESTSGDDSV LIECSARDIL VKGVDESGAN RFTVLFPSGT
     PLPARRQHTL QAPGSISSVC LELYESEGKN SVKEETKFAQ VVLQDLDKKE NGLRDILAVL
     TMKRDGSLQV TCTDQETGKC EAITVEVAS