ID   HSP7E_XENTR             Reviewed;         508 AA.
AC   Q5FVX7;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Heat shock 70 kDa protein 14;
GN   Name=hspa14;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ribosome-associated complex (RAC), a complex
CC       involved in folding or maintaining nascent polypeptides in a folding-
CC       competent state. {ECO:0000250}.
CC   -!- SUBUNIT: Component of ribosome-associated complex (RAC). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; BC089721; AAH89721.1; -; mRNA.
DR   RefSeq; NP_001015780.1; NM_001015780.1.
DR   AlphaFoldDB; Q5FVX7; -.
DR   SMR; Q5FVX7; -.
DR   PaxDb; Q5FVX7; -.
DR   DNASU; 548497; -.
DR   Ensembl; ENSXETT00000019988; ENSXETP00000019988; ENSXETG00000009112.
DR   GeneID; 548497; -.
DR   KEGG; xtr:548497; -.
DR   CTD; 51182; -.
DR   Xenbase; XB-GENE-5932856; hspa14.
DR   eggNOG; KOG0101; Eukaryota.
DR   HOGENOM; CLU_005965_0_3_1; -.
DR   InParanoid; Q5FVX7; -.
DR   OMA; TSVFHYR; -.
DR   OrthoDB; 646813at2759; -.
DR   PhylomeDB; Q5FVX7; -.
DR   TreeFam; TF105045; -.
DR   Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009112; Expressed in embryo and 14 other tissues.
DR   ExpressionAtlas; Q5FVX7; differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd10238; HSPA14-like_NBD; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR042049; HSPA14_NBD.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..508
FT                   /note="Heat shock 70 kDa protein 14"
FT                   /id="PRO_0000405830"
SQ   SEQUENCE   508 AA;  54520 MW;  E7D5E31349B29A1E CRC64;
     MAAIGVHLGC TCACVAVYKD GRADVVANDA GDRVTPAVVG FLEKETIVGL AAKQSRVRNA
     TNTIVKVKQI LGRSYGDPHT QKHISESKCI VVEKVGKPKY EIDTGETQKF VSSEDVAKLI
     FSKMKETAQS ALGSDVNDVV ITVPFDFGES QKKALGEAAT AAGFSILRMI HEPSAALLAY
     GIGQESPTGK SNVLVYKLGG TSLSVTVIEV NSGIYRVLAT STYDDIGGIC FTEALAQHLA
     SEFQRTYKQD IRGNARAMMK LMNSADVAKH ALSTLGSSNC FVDSLYDGID FDCNVSRARF
     ELICSSLFNQ CIDPIKKLLE QIGFKANDVN QVVLCGGSAR IPKLQQLIKD LFPEVEMLSS
     IPPDEVIPVG AAIQAGILIG KENLSTDLDT ITIECSASDI LVKETDESGD NKFTVLLPSG
     TPLPARRQHV LQAPGHISSV CLELYESGGK SPVESKFAQI VLKDLQKKAS GVHDILTVLT
     MKRDGSLHIT CTDKDSGKSE MITVEETP