HSP7F_CANAL
ID HSP7F_CANAL Reviewed; 701 AA.
AC Q96VB9; A0A1D8PDQ1; P83785; Q5AA49;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Heat shock protein homolog SSE1;
DE AltName: Full=Chaperone protein MSI3;
GN Name=MSI3; Synonyms=SSE1; OrderedLocusNames=CAALFM_C106100CA;
GN ORFNames=CaO19.2435, CaO19.9971;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INTERACTION WITH CGR1.
RC STRAIN=ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060;
RX PubMed=12518318; DOI=10.1002/yea.952;
RA Cho T., Toyoda M., Sudoh M., Nakashima Y., Calderone R.A., Kaminishi H.;
RT "Isolation and sequencing of the Candida albicans MSI3, a putative novel
RT member of the HSP70 family.";
RL Yeast 20:149-156(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [5]
RP PROTEIN SEQUENCE OF 26-34, SUBCELLULAR LOCATION, AND ANTIGENICITY.
RC STRAIN=SC5314 / ATCC MYA-2876; TISSUE=Protoplast;
RX PubMed=15378761; DOI=10.1002/pmic.200400903;
RA Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.;
RT "Proteomics-based identification of novel Candida albicans antigens for
RT diagnosis of systemic candidiasis in patients with underlying hematological
RT malignancies.";
RL Proteomics 4:3084-3106(2004).
CC -!- SUBUNIT: Interacts with CGR1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15378761}.
CC -!- MISCELLANEOUS: Has antigenic properties. Elicits a specific immune
CC response in systemic candidiasis human patients undergoing malignant
CC hematological disorders.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB061274; BAB71816.1; -; Genomic_DNA.
DR EMBL; CP017623; AOW26274.1; -; Genomic_DNA.
DR RefSeq; XP_718458.1; XM_713365.1.
DR AlphaFoldDB; Q96VB9; -.
DR SMR; Q96VB9; -.
DR BioGRID; 1222907; 1.
DR STRING; 237561.Q96VB9; -.
DR PRIDE; Q96VB9; -.
DR GeneID; 3639821; -.
DR KEGG; cal:CAALFM_C106100CA; -.
DR CGD; CAL0000182153; MSI3.
DR VEuPathDB; FungiDB:C1_06100C_A; -.
DR eggNOG; KOG0103; Eukaryota.
DR HOGENOM; CLU_005965_5_1_1; -.
DR InParanoid; Q96VB9; -.
DR OMA; AYDRHFG; -.
DR OrthoDB; 406172at2759; -.
DR PRO; PR:Q96VB9; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IDA:CGD.
DR GO; GO:0016887; F:ATP hydrolysis activity; IDA:CGD.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0042277; F:peptide binding; IDA:CGD.
DR GO; GO:0006457; P:protein folding; IDA:CGD.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 2.60.34.10; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF100934; SSF100934; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS01036; HSP70_3; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Chaperone; Cytoplasm; Direct protein sequencing;
KW Nucleotide-binding; Reference proteome; Stress response.
FT CHAIN 1..701
FT /note="Heat shock protein homolog SSE1"
FT /id="PRO_0000078392"
FT REGION 651..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 409
FT /note="E -> EE (in strain: NBRC 1060)"
SQ SEQUENCE 701 AA; 78525 MW; C968DD3E0BB365BC CRC64;
MSIPFGVDLG NNNTVIACAK NRGIDIVVNE VSNRSTPSLV GFGHKSRYLG ESAKNQQTSN
IKNTVDNLKR IVGLPHDHPD FEIEKKFFTI PLIKNEVDGG VSGKVKYLTK NHEFTATQLL
AMYLDKIKDT ALKETKGNIS DICLSVPGWY TEKQRRAAAD ACKIAGLNPV RIVNEVTAAA
VGYGVFKAGE LPEDEYKKVA FVDVGHSSYQ VSIAAVKKGE LKILGSAYDK HFGGRNFDFA
IAEHFAKEFK SKYKIDVHEN PKAFYRVLVA AEKLKKVLSA NTQAPFNIES VMNDVDVSSS
LTREELEELV QPLLDRINVP IETALKDAGI TVDELDSIEV IGGSSRIPAV KTRISEIFGK
PLSFTLNQDE AIAKGNAYIC ACHSPTVRVR PFKFEDYNQY TVSYFWDKED EEDDHLEVFP
KGGLFPSTKI ITLFRKGPSF EIEAKYTKPE ELPKGTELHI AKWKISGVVP NEGESSIATK
IKLRNDPSGF YTIESAHTVE EQIVKELIEP AEGEEVDEDA EPQYREVKKL VKKNDLTIEC
ESAALPDAEL QAFIEKEASM VMEDKLVFDT EERKNQLEEY IYELRGKLDE EYKDFASDQE
KEKLSGLLMK AEDWLYEDGE DSTKAKYIAK YEELASIGNV IKGRYLAKEQ EKKEQYRQKQ
EAAQAAAMAE KMAAQREASK KQESSSSGKN NKDTEGDVDM D
