HSP88_DICDI
ID HSP88_DICDI Reviewed; 772 AA.
AC Q6TMK3; Q54GD7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Heat shock protein 88;
DE AltName: Full=Heat shock 70-related protein;
GN Name=hspH; ORFNames=DDB_G0290187;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT "Identification of genes dependent on the MADS box transcription factor
RT SrfA in Dictyostelium discoideum development.";
RL Eukaryot. Cell 3:564-566(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: May function in protein folding and assembly, and disassembly
CC of protein complexes. {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels at earlier developmental
CC stages and induced at high levels during culmination dependent on
CC transcription factor srfA. {ECO:0000269|PubMed:15075287}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR EMBL; AY392430; AAQ98872.1; -; Genomic_DNA.
DR EMBL; AAFI02000161; EAL62315.1; -; Genomic_DNA.
DR RefSeq; XP_635841.1; XM_630749.1.
DR AlphaFoldDB; Q6TMK3; -.
DR SMR; Q6TMK3; -.
DR STRING; 44689.DDB0191276; -.
DR PaxDb; Q6TMK3; -.
DR PRIDE; Q6TMK3; -.
DR EnsemblProtists; EAL62315; EAL62315; DDB_G0290187.
DR GeneID; 8627549; -.
DR KEGG; ddi:DDB_G0290187; -.
DR dictyBase; DDB_G0290187; hspH.
DR eggNOG; KOG0103; Eukaryota.
DR HOGENOM; CLU_005965_5_1_1; -.
DR InParanoid; Q6TMK3; -.
DR OMA; AHFLVQK; -.
DR PhylomeDB; Q6TMK3; -.
DR PRO; PR:Q6TMK3; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; ISS:dictyBase.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 2.60.34.10; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF100934; SSF100934; 2.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 1: Evidence at protein level;
KW ATP-binding; Chaperone; Nucleotide-binding; Reference proteome;
KW Stress response.
FT CHAIN 1..772
FT /note="Heat shock protein 88"
FT /id="PRO_0000327976"
FT REGION 496..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 86008 MW; 29A4CF49B01BF754 CRC64;
MSFVVGFDFG TKNCTIAVAQ KGGVDVIANE VSNRLTPSMV SFGEKERYLG ESALTNQLRN
IRNTITNIKR FIGQEFKTDT VQEELKHEMF QSYEMDNGFV GYNVTYAGEQ CSFSSEAILG
MLFGKLKKTT EAFVNNPVRD VVISVPVFWN DYQRRAILNA GSIAGLNIIR LINETTATAL
SYGIYKEWSE TDPTNVLFVD VGDSATSVSA VQYKKGQLKV LGTASNPNIG SRVFDETLVK
HFAKEFQTKY KINVFENKKA LIRLRQACEK VKKILSSNNE APVSIDSLMD DKDVKGMIDR
ATFEELANDD MNTIVEPLQR LLSELQMTPD QFQSIEITGG GTRSTSLQKK LSEVLGRDLS
KTINSEESVC RGAALQCAML SPVFRVRPFA VNDVASYPVS VHFKSVSGVE QKLDLFNLKS
AIPTPKPLRI SFPVTKAEGF EIVVNSTFGT IATVKVDNIP AFTNKSSIKA KVWLDIHGIF
HIDEVKLVEQ IPEEETAAPA ETPAETPANG EAAKPAEEKK VKVKETSLVF TTSRKGLTNE
LLKAAIEEEG RMQASDLLAI ETAEKKNALE SYIYDMRSKL QSSLKEYVTP ADAETFMTQL
NKQMDWLESE EGEDQTKSVY AGKLEELRRL GNPIQKRKQD LEDYPDAVQT LKNIASYVKN
EAMIPGERYD HIEKEEKEKL CKDCDDAVEW IDALVAKQQA TPKTQPCIIN TTEVLAKKTQ
LEVTAKMILG KPKPKPVEVP KEEPKDTPME SKDAPAEEPV ATKDQKMDDI LD
