ID   HSP88_NEUCR             Reviewed;         707 AA.
AC   O74225; Q7RVE6; V5IPJ6;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Heat shock protein hsp88;
GN   Name=hsp88; ORFNames=NCU05269;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 431-436; 439-445; 536-549;
RP   575-586; 596-602 AND 689-697, AND CHARACTERIZATION.
RX   PubMed=9556627; DOI=10.1074/jbc.273.18.11335;
RA   Plesofsky-Vig N., Brambl R.;
RT   "Characterization of an 88-kDa heat shock protein of Neurospora crassa that
RT   interacts with Hsp30.";
RL   J. Biol. Chem. 273:11335-11341(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SUBUNIT: Binds hsp30 independent of temperature or substrate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- INDUCTION: By heat shock.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AF069523; AAC23862.1; -; mRNA.
DR   EMBL; CM002239; ESA43073.1; -; Genomic_DNA.
DR   EMBL; CM002239; ESA43074.1; -; Genomic_DNA.
DR   RefSeq; XP_011394150.1; XM_011395848.1.
DR   RefSeq; XP_011394151.1; XM_011395849.1.
DR   AlphaFoldDB; O74225; -.
DR   SMR; O74225; -.
DR   STRING; 5141.EFNCRP00000005028; -.
DR   PRIDE; O74225; -.
DR   EnsemblFungi; ESA43073; ESA43073; NCU05269.
DR   EnsemblFungi; ESA43074; ESA43074; NCU05269.
DR   GeneID; 3877907; -.
DR   KEGG; ncr:NCU05269; -.
DR   VEuPathDB; FungiDB:NCU05269; -.
DR   HOGENOM; CLU_005965_5_1_1; -.
DR   InParanoid; O74225; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Direct protein sequencing; Nucleotide-binding;
KW   Reference proteome; Stress response.
FT   CHAIN           1..707
FT                   /note="Heat shock protein hsp88"
FT                   /id="PRO_0000078373"
FT   REGION          662..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  78674 MW;  8B077E8CC08BB4C1 CRC64;
     MSVVGVDFGA LNTVIAVARN RGVDVITNEV SNRATPSLVG FGPKSRYIGE PAKTQEISNL
     KNTVGCLKRL AGRTLDDPDV AIEQQFISAT LVDVNGEVGA EVTYLGEKRK FSATELIAMF
     MSKIKQTTQA EVKVAVQELV LSVPAWFTDK QRRSILDAAE IAGLRPLRLI NDTTAAALGW
     GITKLDLPGP EEKPRRVAFV DVGYSNYTCS IVEFKKGELS VKSTACDRHF GGRNFDKALL
     DHLHKEFLGK YKIDIFTNPK AVCRVLAAAE KLKKILSANQ QAPLNIESLM NDIDVRAMIT
     RQEFEAMVEP LLAKVHVPLE QALADAKLTK DDIDIIEVVG GGSRVPSVKE RIQAFFGKQL
     SFTMNQDEAI ARGCAFSCAI LSPVFKVRDF QVQDIINYPI EFTWEKDADI PDEDTSLVVF
     NKGNVLPSTK ILTFYRKQPF DLEARYTNPE ELPGKTSPFI GRFSIKGVHA TEGPEDFMIC
     KLKARINIHG ILNVESAYYV EDQEVEEEVK DENGDVVMEG DKPKTRKVKK QVRKGELPVV
     SATPSLDPAA KNAAIEREQA MIMEDKLVAD TEEKKNELET YIYDLRNKLD DQYADLASEE
     EKEKIRAKLM EVEDWLYDEG DDATKAVYVA KIEEIRALAG PVVQRYFDKV EAERQALQEK
     LEAEKAAKKA EEEARKAKEA AEKAAQEGAK DDEMTDADAP KPVVEEA