ID   HSP90_RABIT             Reviewed;          47 AA.
AC   P11500;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Heat shock protein HSP 90;
DE   AltName: Full=Eukaryotic peptide initiation factor 2 kinase, alpha-chain-associated phosphopeptide;
DE   Flags: Fragments;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-47.
RC   TISSUE=Reticulocyte;
RX   PubMed=3427028; DOI=10.1021/bi00395a003;
RA   Rose D.W., Wettenhall R.E.H., Kudlicki W., Kramer G., Hardesty B.;
RT   "The 90-kilodalton peptide of the heme-regulated eIF-2 alpha kinase has
RT   sequence similarity with the 90-kilodalton heat shock protein.";
RL   Biochemistry 26:6583-6587(1987).
CC   -!- FUNCTION: Putative molecular chaperone that may promote the maturation,
CC       structural maintenance and proper regulation of specific target
CC       proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P11500; Q16543: CDC37; Xeno; NbExp=3; IntAct=EBI-640126, EBI-295634;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is found associated with eIF-2-alpha
CC       kinase.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family. {ECO:0000305}.
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DR   PIR; A29743; A29743.
DR   PIR; B29743; B29743.
DR   AlphaFoldDB; P11500; -.
DR   DIP; DIP-70N; -.
DR   IntAct; P11500; 2.
DR   ChEMBL; CHEMBL1667702; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   ATP-binding; Chaperone; Cytoplasm; Direct protein sequencing;
KW   Nucleotide-binding; Reference proteome; Stress response.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:3427028"
FT   CHAIN           2..>47
FT                   /note="Heat shock protein HSP 90"
FT                   /id="PRO_0000062921"
FT   NON_CONS        33..34
FT                   /evidence="ECO:0000305"
FT   NON_TER         47
SQ   SEQUENCE   47 AA;  5295 MW;  72E9934BA144C184 CRC64;
     MPEEVQTQDQ PMETFAVQTF AFQAEIAQLM SLIYESLTDP SKLDSGK