HSPB2_HUMAN
ID HSPB2_HUMAN Reviewed; 182 AA.
AC Q16082; Q6I9U7;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Heat shock protein beta-2;
DE Short=HspB2;
DE AltName: Full=DMPK-binding protein;
DE Short=MKBP;
GN Name=HSPB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9344664; DOI=10.1006/geno.1997.4956;
RA Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.;
RT "Identification and characterization of the gene encoding a new member of
RT the alpha-crystallin/small hsp family, closely linked to the alphaB-
RT crystallin gene in a head-to-head manner.";
RL Genomics 45:386-394(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH DMPK.
RC TISSUE=Muscle;
RX PubMed=9490724; DOI=10.1083/jcb.140.5.1113;
RA Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I.,
RA Ishiura S., Arahata K., Ohno S.;
RT "MKBP, a novel member of the small heat shock protein family, binds and
RT activates the myotonic dystrophy protein kinase.";
RL J. Cell Biol. 140:1113-1124(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-111.
RG NIEHS SNPs program;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
RX PubMed=8227983; DOI=10.1007/bf03348900;
RA Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M.;
RT "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of
RT molecular genetics.";
RL J. Endocrinol. Invest. 16:533-540(1993).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=19464326; DOI=10.1016/j.bbamcr.2009.05.005;
RA Vos M.J., Kanon B., Kampinga H.H.;
RT "HSPB7 is a SC35 speckle resident small heat shock protein.";
RL Biochim. Biophys. Acta 1793:1343-1353(2009).
CC -!- FUNCTION: May regulate the kinase DMPK. {ECO:0000269|PubMed:9490724}.
CC -!- SUBUNIT: Interacts with DMPK; may enhance its kinase activity.
CC {ECO:0000269|PubMed:9490724}.
CC -!- INTERACTION:
CC Q16082; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-739395, EBI-2809489;
CC Q16082; P05067: APP; NbExp=3; IntAct=EBI-739395, EBI-77613;
CC Q16082; O95817: BAG3; NbExp=3; IntAct=EBI-739395, EBI-747185;
CC Q16082; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-739395, EBI-745073;
CC Q16082; Q6AI39: BICRAL; NbExp=3; IntAct=EBI-739395, EBI-1012434;
CC Q16082; Q96LK0: CEP19; NbExp=6; IntAct=EBI-739395, EBI-741885;
CC Q16082; P02511: CRYAB; NbExp=3; IntAct=EBI-739395, EBI-739060;
CC Q16082; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-739395, EBI-744099;
CC Q16082; P17482: HOXB9; NbExp=3; IntAct=EBI-739395, EBI-745290;
CC Q16082; Q9UJY1: HSPB8; NbExp=3; IntAct=EBI-739395, EBI-739074;
CC Q16082; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-739395, EBI-2556193;
CC Q16082; P25800: LMO1; NbExp=3; IntAct=EBI-739395, EBI-8639312;
CC Q16082; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-739395, EBI-11742507;
CC Q16082; Q8IVT2: MISP; NbExp=3; IntAct=EBI-739395, EBI-2555085;
CC Q16082; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-739395, EBI-11022007;
CC Q16082; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-739395, EBI-1389308;
CC Q16082; P0CG20: PRR35; NbExp=3; IntAct=EBI-739395, EBI-11986293;
CC Q16082; O75679: RFPL3; NbExp=4; IntAct=EBI-739395, EBI-10188956;
CC Q16082; Q96RF0: SNX18; NbExp=3; IntAct=EBI-739395, EBI-298169;
CC Q16082; O43711: TLX3; NbExp=3; IntAct=EBI-739395, EBI-3939165;
CC Q16082; Q14119: VEZF1; NbExp=3; IntAct=EBI-739395, EBI-11980193;
CC Q16082; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-739395, EBI-12040603;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus
CC {ECO:0000269|PubMed:19464326}. Note=Localizes to nuclear foci.
CC -!- TISSUE SPECIFICITY: Expressed preferentially in skeletal muscle and
CC heart but not in the lens.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/hspb2/";
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DR EMBL; U75898; AAB82757.1; -; Genomic_DNA.
DR EMBL; D89617; BAA24004.1; -; mRNA.
DR EMBL; CR457408; CAG33689.1; -; mRNA.
DR EMBL; AY208910; AAO18081.1; -; Genomic_DNA.
DR EMBL; BC109393; AAI09394.1; -; mRNA.
DR EMBL; S67070; AAB28816.1; -; mRNA.
DR CCDS; CCDS8352.1; -.
DR RefSeq; NP_001532.1; NM_001541.3.
DR PDB; 6F2R; X-ray; 3.90 A; A/C/D/E/F/G/I/J/K=1-182.
DR PDBsum; 6F2R; -.
DR AlphaFoldDB; Q16082; -.
DR SMR; Q16082; -.
DR BioGRID; 109548; 135.
DR IntAct; Q16082; 175.
DR MINT; Q16082; -.
DR STRING; 9606.ENSP00000302476; -.
DR iPTMnet; Q16082; -.
DR PhosphoSitePlus; Q16082; -.
DR BioMuta; HSPB2; -.
DR MassIVE; Q16082; -.
DR MaxQB; Q16082; -.
DR PaxDb; Q16082; -.
DR PeptideAtlas; Q16082; -.
DR PRIDE; Q16082; -.
DR ProteomicsDB; 60830; -.
DR Antibodypedia; 32089; 547 antibodies from 31 providers.
DR DNASU; 3316; -.
DR Ensembl; ENST00000304298.4; ENSP00000302476.3; ENSG00000170276.6.
DR GeneID; 3316; -.
DR KEGG; hsa:3316; -.
DR MANE-Select; ENST00000304298.4; ENSP00000302476.3; NM_001541.4; NP_001532.1.
DR UCSC; uc001pmg.3; human.
DR CTD; 3316; -.
DR DisGeNET; 3316; -.
DR GeneCards; HSPB2; -.
DR HGNC; HGNC:5247; HSPB2.
DR HPA; ENSG00000170276; Group enriched (heart muscle, skeletal muscle, tongue).
DR MIM; 602179; gene.
DR neXtProt; NX_Q16082; -.
DR OpenTargets; ENSG00000170276; -.
DR PharmGKB; PA29512; -.
DR VEuPathDB; HostDB:ENSG00000170276; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00940000161288; -.
DR HOGENOM; CLU_095001_1_0_1; -.
DR InParanoid; Q16082; -.
DR OMA; PHAYPMS; -.
DR OrthoDB; 1187096at2759; -.
DR PhylomeDB; Q16082; -.
DR PathwayCommons; Q16082; -.
DR SignaLink; Q16082; -.
DR BioGRID-ORCS; 3316; 6 hits in 1049 CRISPR screens.
DR GeneWiki; HSPB2; -.
DR GenomeRNAi; 3316; -.
DR Pharos; Q16082; Tbio.
DR PRO; PR:Q16082; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q16082; protein.
DR Bgee; ENSG00000170276; Expressed in right atrium auricular region and 93 other tissues.
DR Genevisible; Q16082; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:ProtInc.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0008047; F:enzyme activator activity; TAS:ProtInc.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IBA:GO_Central.
DR GO; GO:0006986; P:response to unfolded protein; NAS:ProtInc.
DR GO; GO:0007525; P:somatic muscle development; IEA:Ensembl.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR003090; Alpha-crystallin_N.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640; PTHR45640; 1.
DR Pfam; PF00525; Crystallin; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Nucleus; Reference proteome; Stress response.
FT CHAIN 1..182
FT /note="Heat shock protein beta-2"
FT /id="PRO_0000125933"
FT DOMAIN 55..163
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT VARIANT 111
FT /note="G -> S (in dbSNP:rs4252589)"
FT /evidence="ECO:0000269|Ref.4"
FT /id="VAR_016316"
SQ SEQUENCE 182 AA; 20233 MW; 7586DCE8FBD19F6D CRC64;
MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS
RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT
YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV
EP
