HSPB2_MOUSE
ID HSPB2_MOUSE Reviewed; 182 AA.
AC Q99PR8; E9QKE3; Q9CZC2;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Heat shock protein beta-2;
DE Short=HspB2;
GN Name=Hspb2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv; TISSUE=Liver;
RA Iwaki A., Ijichi N.;
RT "Isolation of the murine HSPB2 gene.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May regulate the kinase DMPK. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DMPK; may enhance its kinase activity.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Localizes to nuclear foci. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q99PR8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99PR8-2; Sequence=VSP_010160;
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; AF126248; AAK13576.1; -; Genomic_DNA.
DR EMBL; AK012780; BAB28465.1; -; mRNA.
DR EMBL; AC113987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC123614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS23171.1; -. [Q99PR8-1]
DR CCDS; CCDS90564.1; -. [Q99PR8-2]
DR RefSeq; NP_001158180.1; NM_001164708.1. [Q99PR8-2]
DR RefSeq; NP_077761.3; NM_024441.3. [Q99PR8-1]
DR AlphaFoldDB; Q99PR8; -.
DR SMR; Q99PR8; -.
DR BioGRID; 213316; 70.
DR IntAct; Q99PR8; 1.
DR STRING; 10090.ENSMUSP00000042374; -.
DR PhosphoSitePlus; Q99PR8; -.
DR MaxQB; Q99PR8; -.
DR PaxDb; Q99PR8; -.
DR PRIDE; Q99PR8; -.
DR ProteomicsDB; 273046; -. [Q99PR8-1]
DR ProteomicsDB; 273047; -. [Q99PR8-2]
DR DNASU; 69253; -.
DR Ensembl; ENSMUST00000042790; ENSMUSP00000042374; ENSMUSG00000038086. [Q99PR8-1]
DR Ensembl; ENSMUST00000217159; ENSMUSP00000148970; ENSMUSG00000038086. [Q99PR8-2]
DR GeneID; 69253; -.
DR KEGG; mmu:69253; -.
DR UCSC; uc009pkj.2; mouse. [Q99PR8-1]
DR UCSC; uc009pkk.2; mouse. [Q99PR8-2]
DR CTD; 3316; -.
DR MGI; MGI:1916503; Hspb2.
DR VEuPathDB; HostDB:ENSMUSG00000038086; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00940000161288; -.
DR HOGENOM; CLU_095001_1_0_1; -.
DR InParanoid; Q99PR8; -.
DR OMA; PHAYPMS; -.
DR PhylomeDB; Q99PR8; -.
DR TreeFam; TF105049; -.
DR BioGRID-ORCS; 69253; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Hspb2; mouse.
DR PRO; PR:Q99PR8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q99PR8; protein.
DR Bgee; ENSMUSG00000038086; Expressed in interventricular septum and 144 other tissues.
DR Genevisible; Q99PR8; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; ISO:MGI.
DR GO; GO:0007525; P:somatic muscle development; IGI:MGI.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR003090; Alpha-crystallin_N.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640; PTHR45640; 1.
DR Pfam; PF00525; Crystallin; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome;
KW Stress response.
FT CHAIN 1..182
FT /note="Heat shock protein beta-2"
FT /id="PRO_0000125934"
FT DOMAIN 55..163
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT VAR_SEQ 32..125
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010160"
FT CONFLICT 54
FT /note="A -> T (in Ref. 1; AAK13576)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 182 AA; 20375 MW; 40E7E69EEB887A39 CRC64;
MSGRTVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAARAGEGA
RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT
YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEIARV
EP
