ID   HSPB2_RAT               Reviewed;         182 AA.
AC   O35878;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Heat shock protein beta-2;
DE            Short=HspB2;
GN   Name=Hspb2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=9344664; DOI=10.1006/geno.1997.4956;
RA   Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.;
RT   "Identification and characterization of the gene encoding a new member of
RT   the alpha-crystallin/small hsp family, closely linked to the alphaB-
RT   crystallin gene in a head-to-head manner.";
RL   Genomics 45:386-394(1997).
CC   -!- FUNCTION: May regulate the kinase DMPK. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DMPK; may enhance its kinase activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to nuclear foci. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U75899; AAB82758.1; -; Genomic_DNA.
DR   RefSeq; NP_569115.1; NM_130431.1.
DR   AlphaFoldDB; O35878; -.
DR   SMR; O35878; -.
DR   CORUM; O35878; -.
DR   STRING; 10116.ENSRNOP00000013960; -.
DR   iPTMnet; O35878; -.
DR   PhosphoSitePlus; O35878; -.
DR   PaxDb; O35878; -.
DR   PRIDE; O35878; -.
DR   GeneID; 161476; -.
DR   KEGG; rno:161476; -.
DR   UCSC; RGD:70914; rat.
DR   CTD; 3316; -.
DR   RGD; 70914; Hspb2.
DR   VEuPathDB; HostDB:ENSRNOG00000051792; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   HOGENOM; CLU_095001_1_0_1; -.
DR   InParanoid; O35878; -.
DR   OMA; PHAYPMS; -.
DR   OrthoDB; 1187096at2759; -.
DR   PhylomeDB; O35878; -.
DR   TreeFam; TF105049; -.
DR   PRO; PR:O35878; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000010402; Expressed in heart and 19 other tissues.
DR   Genevisible; O35878; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IDA:RGD.
DR   GO; GO:0007525; P:somatic muscle development; ISO:RGD.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR003090; Alpha-crystallin_N.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   PANTHER; PTHR45640; PTHR45640; 1.
DR   Pfam; PF00525; Crystallin; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Stress response.
FT   CHAIN           1..182
FT                   /note="Heat shock protein beta-2"
FT                   /id="PRO_0000125935"
FT   DOMAIN          55..163
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
SQ   SEQUENCE   182 AA;  20347 MW;  4547E53EED9AEA39 CRC64;
     MSGRTVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAARAGEGG
     RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT
     YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEVARV
     EP