ID   HSPB3_BOVIN             Reviewed;         149 AA.
AC   Q2KHU9;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Heat shock protein beta-3;
DE            Short=HspB3;
GN   Name=HSPB3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of actin polymerization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Translocates to nuclear foci during heat shock. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; BC112874; AAI12875.1; -; mRNA.
DR   RefSeq; NP_001040035.1; NM_001046570.2.
DR   AlphaFoldDB; Q2KHU9; -.
DR   SMR; Q2KHU9; -.
DR   STRING; 9913.ENSBTAP00000030791; -.
DR   PaxDb; Q2KHU9; -.
DR   Ensembl; ENSBTAT00000030821; ENSBTAP00000030791; ENSBTAG00000022714.
DR   GeneID; 616007; -.
DR   KEGG; bta:616007; -.
DR   CTD; 8988; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022714; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   GeneTree; ENSGT00940000161247; -.
DR   HOGENOM; CLU_151649_0_0_1; -.
DR   InParanoid; Q2KHU9; -.
DR   OMA; HGPRMDE; -.
DR   OrthoDB; 1187096at2759; -.
DR   TreeFam; TF105049; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000022714; Expressed in tongue muscle and 65 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   CDD; cd06477; ACD_HspB3_Like; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR033894; HSPB3.
DR   PANTHER; PTHR47097; PTHR47097; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Stress response.
FT   CHAIN           1..149
FT                   /note="Heat shock protein beta-3"
FT                   /id="PRO_0000246076"
FT   DOMAIN          47..149
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
SQ   SEQUENCE   149 AA;  16722 MW;  10020106766950AC CRC64;
     MAKIILRHLI ETPVRYEQEF EARGLEDCRL DHALYALPGP TTVDLGKARA AQAPPVDAAE
     MPPQRGESRF QVLLDVVQFL PEDIIIQTFE GWLLIKAQHG TRMDEHGFIS RSFTRQYKLP
     DGIETKDLSA ILCHDGILVV EVKDSAGTK