ID   HSPB3_MOUSE             Reviewed;         154 AA.
AC   Q9QZ57; Q569N3;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Heat shock protein beta-3;
DE            Short=HspB3;
GN   Name=Hspb3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Tam W.H., Chan K.K., Tsui S.K.W., Fung K.P., Lee C.Y., Waye M.M.Y.;
RT   "Cloning and characterization of mouse small heat shock protein B3
RT   (HSPB3).";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Eye, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inhibitor of actin polymerization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Translocates to nuclear foci during heat shock. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; AF203375; AAF09589.1; -; mRNA.
DR   EMBL; AK009633; BAB26404.1; -; mRNA.
DR   EMBL; BC065388; AAH65388.1; -; mRNA.
DR   EMBL; BC092376; AAH92376.1; -; mRNA.
DR   CCDS; CCDS26785.1; -.
DR   RefSeq; NP_064344.1; NM_019960.2.
DR   AlphaFoldDB; Q9QZ57; -.
DR   SMR; Q9QZ57; -.
DR   STRING; 10090.ENSMUSP00000054193; -.
DR   PhosphoSitePlus; Q9QZ57; -.
DR   PaxDb; Q9QZ57; -.
DR   PRIDE; Q9QZ57; -.
DR   ProteomicsDB; 267168; -.
DR   Antibodypedia; 23356; 50 antibodies from 14 providers.
DR   DNASU; 56534; -.
DR   Ensembl; ENSMUST00000054650; ENSMUSP00000054193; ENSMUSG00000051456.
DR   GeneID; 56534; -.
DR   KEGG; mmu:56534; -.
DR   UCSC; uc007rxi.2; mouse.
DR   CTD; 8988; -.
DR   MGI; MGI:1928479; Hspb3.
DR   VEuPathDB; HostDB:ENSMUSG00000051456; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   GeneTree; ENSGT00940000161247; -.
DR   HOGENOM; CLU_151649_0_0_1; -.
DR   InParanoid; Q9QZ57; -.
DR   OMA; HGPRMDE; -.
DR   OrthoDB; 1187096at2759; -.
DR   PhylomeDB; Q9QZ57; -.
DR   TreeFam; TF105049; -.
DR   BioGRID-ORCS; 56534; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Hspb3; mouse.
DR   PRO; PR:Q9QZ57; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q9QZ57; protein.
DR   Bgee; ENSMUSG00000051456; Expressed in temporalis muscle and 95 other tissues.
DR   Genevisible; Q9QZ57; MM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   CDD; cd06477; ACD_HspB3_Like; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR033894; HSPB3.
DR   PANTHER; PTHR47097; PTHR47097; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Stress response.
FT   CHAIN           1..154
FT                   /note="Heat shock protein beta-3"
FT                   /id="PRO_0000125937"
FT   DOMAIN          57..154
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   REGION          48..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   154 AA;  17230 MW;  ECBAAD45221FE2E3 CRC64;
     MAKIILRHLI ETPVRYQEEF EARGLEDCRL DHTLYALPGP TIEDLSKARG AGTPQALAED
     SASTEKPPGE GKSRFQILLD VVQFLPEDII IQTFEGWLLI KAQHGTRMDE HGFISRSFTR
     QYKLPDGVET KDLSAILCHD GILVVEVKDS LGTK