ID   HSPB3_RAT               Reviewed;         152 AA.
AC   Q9QZ58;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Heat shock protein beta-3;
DE            Short=HspB3;
GN   Name=Hspb3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Tam W.H., Chan K.K., Tsui S.K.W., Fung K.P., Lee C.Y., Waye M.M.Y.;
RT   "Cloning and characterization of a rat small heat shock protein B3
RT   (HSPB3).";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of actin polymerization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Translocates to nuclear foci during heat shock. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; AF203374; AAF09588.1; -; mRNA.
DR   RefSeq; NP_113938.1; NM_031750.1.
DR   AlphaFoldDB; Q9QZ58; -.
DR   SMR; Q9QZ58; -.
DR   CORUM; Q9QZ58; -.
DR   STRING; 10116.ENSRNOP00000014627; -.
DR   PaxDb; Q9QZ58; -.
DR   PRIDE; Q9QZ58; -.
DR   GeneID; 78951; -.
DR   KEGG; rno:78951; -.
DR   CTD; 8988; -.
DR   RGD; 68345; Hspb3.
DR   eggNOG; KOG3591; Eukaryota.
DR   InParanoid; Q9QZ58; -.
DR   OrthoDB; 1187096at2759; -.
DR   PhylomeDB; Q9QZ58; -.
DR   PRO; PR:Q9QZ58; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   CDD; cd06477; ACD_HspB3_Like; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR033894; HSPB3.
DR   PANTHER; PTHR47097; PTHR47097; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Stress response.
FT   CHAIN           1..152
FT                   /note="Heat shock protein beta-3"
FT                   /id="PRO_0000125938"
FT   DOMAIN          55..152
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   REGION          48..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   152 AA;  17210 MW;  DAC532E8A00484E5 CRC64;
     MAKIILRHLI ETPVRYQEEF EARGLEDCRL DHALYALPGP TIEDLRKARG TPKALAEDSD
     SAETPPGEGK SRFQILLDVV QFLPEDIIIQ TFEGWLLIKA QHGTRMDEHG FISRSFTRQY
     KLPDGVETKD LSAILCHDGI LVVEVKDPLE TK