HSPB7_HUMAN
ID HSPB7_HUMAN Reviewed; 170 AA.
AC Q9UBY9; B3KQ37; C9K0Y0; Q9NU17;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Heat shock protein beta-7;
DE Short=HspB7;
DE AltName: Full=Cardiovascular heat shock protein;
DE Short=cvHsp;
GN Name=HSPB7; Synonyms=CVHSP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Heart;
RX PubMed=10593960; DOI=10.1074/jbc.274.51.36592;
RA Krief S., Faivre J.-F., Robert P., Le Douarin B., Brument-Larignon N.,
RA Lefrere I., Bouzyk M.M., Anderson K.M., Greller L.D., Tobin F.L.,
RA Souchet M., Bril A.;
RT "Identification and characterization of cvHsp. A novel human small stress
RT protein selectively expressed in cardiovascular and insulin-sensitive
RT tissues.";
RL J. Biol. Chem. 274:36592-36600(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Salivary gland;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=19464326; DOI=10.1016/j.bbamcr.2009.05.005;
RA Vos M.J., Kanon B., Kampinga H.H.;
RT "HSPB7 is a SC35 speckle resident small heat shock protein.";
RL Biochim. Biophys. Acta 1793:1343-1353(2009).
CC -!- SUBUNIT: Interacts with C-terminal domain of actin-binding protein 280.
CC -!- INTERACTION:
CC Q9UBY9; O95817: BAG3; NbExp=3; IntAct=EBI-739361, EBI-747185;
CC Q9UBY9; Q8WYQ4-2: C22orf15; NbExp=6; IntAct=EBI-739361, EBI-12030460;
CC Q9UBY9; Q8TAP6: CEP76; NbExp=6; IntAct=EBI-739361, EBI-742887;
CC Q9UBY9; Q96D03: DDIT4L; NbExp=5; IntAct=EBI-739361, EBI-742054;
CC Q9UBY9; P63172: DYNLT1; NbExp=3; IntAct=EBI-739361, EBI-1176455;
CC Q9UBY9; P21333-2: FLNA; NbExp=10; IntAct=EBI-739361, EBI-9641086;
CC Q9UBY9; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-739361, EBI-11978177;
CC Q9UBY9; Q9UJY1: HSPB8; NbExp=11; IntAct=EBI-739361, EBI-739074;
CC Q9UBY9; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-739361, EBI-747204;
CC Q9UBY9; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-739361, EBI-350517;
CC Q9UBY9; P78356-2: PIP4K2B; NbExp=3; IntAct=EBI-739361, EBI-11532361;
CC Q9UBY9; Q9H8W4: PLEKHF2; NbExp=6; IntAct=EBI-739361, EBI-742388;
CC Q9UBY9; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-739361, EBI-3957793;
CC Q9UBY9; Q04864: REL; NbExp=3; IntAct=EBI-739361, EBI-307352;
CC Q9UBY9; Q04864-2: REL; NbExp=3; IntAct=EBI-739361, EBI-10829018;
CC Q9UBY9; Q15427: SF3B4; NbExp=3; IntAct=EBI-739361, EBI-348469;
CC Q9UBY9; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-739361, EBI-6872807;
CC Q9UBY9; P15884: TCF4; NbExp=3; IntAct=EBI-739361, EBI-533224;
CC Q9UBY9; P15884-3: TCF4; NbExp=3; IntAct=EBI-739361, EBI-13636688;
CC Q9UBY9; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-739361, EBI-11139477;
CC Q9UBY9; P36406: TRIM23; NbExp=3; IntAct=EBI-739361, EBI-740098;
CC Q9UBY9; Q04323-2: UBXN1; NbExp=3; IntAct=EBI-739361, EBI-11530712;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus
CC {ECO:0000269|PubMed:19464326}. Nucleus, Cajal body
CC {ECO:0000269|PubMed:19464326}. Note=Resides in sub-nuclear structures
CC known as SC35 speckles or nuclear splicing speckles.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UBY9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UBY9-2; Sequence=VSP_002424;
CC Name=3;
CC IsoId=Q9UBY9-3; Sequence=VSP_002425, VSP_002426;
CC -!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in adult and fetal
CC heart, skeletal muscle, and at a much lower levels in adipose tissue
CC and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3
CC are poorly detected in heart.
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; AJ243191; CAB63258.1; -; mRNA.
DR EMBL; AF155908; AAF20022.1; -; mRNA.
DR EMBL; AK057295; BAG51899.1; -; mRNA.
DR EMBL; CR749298; CAH18153.1; -; mRNA.
DR EMBL; AL096775; CAB86671.1; -; Genomic_DNA.
DR EMBL; AL355994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006319; AAH06319.1; -; mRNA.
DR CCDS; CCDS30611.1; -. [Q9UBY9-1]
DR CCDS; CCDS85932.1; -. [Q9UBY9-2]
DR RefSeq; NP_055239.1; NM_014424.4. [Q9UBY9-1]
DR AlphaFoldDB; Q9UBY9; -.
DR SMR; Q9UBY9; -.
DR BioGRID; 118020; 22.
DR IntAct; Q9UBY9; 24.
DR STRING; 9606.ENSP00000310111; -.
DR iPTMnet; Q9UBY9; -.
DR PhosphoSitePlus; Q9UBY9; -.
DR BioMuta; HSPB7; -.
DR UCD-2DPAGE; Q9UBY9; -.
DR jPOST; Q9UBY9; -.
DR MassIVE; Q9UBY9; -.
DR MaxQB; Q9UBY9; -.
DR PaxDb; Q9UBY9; -.
DR PeptideAtlas; Q9UBY9; -.
DR PRIDE; Q9UBY9; -.
DR ProteomicsDB; 84101; -. [Q9UBY9-1]
DR ProteomicsDB; 84102; -. [Q9UBY9-2]
DR ProteomicsDB; 84103; -. [Q9UBY9-3]
DR Antibodypedia; 29049; 271 antibodies from 30 providers.
DR DNASU; 27129; -.
DR Ensembl; ENST00000311890.14; ENSP00000310111.9; ENSG00000173641.18. [Q9UBY9-1]
DR Ensembl; ENST00000487046.1; ENSP00000419477.1; ENSG00000173641.18. [Q9UBY9-2]
DR GeneID; 27129; -.
DR KEGG; hsa:27129; -.
DR MANE-Select; ENST00000311890.14; ENSP00000310111.9; NM_014424.5; NP_055239.1.
DR UCSC; uc001axo.2; human. [Q9UBY9-1]
DR CTD; 27129; -.
DR DisGeNET; 27129; -.
DR GeneCards; HSPB7; -.
DR HGNC; HGNC:5249; HSPB7.
DR HPA; ENSG00000173641; Group enriched (heart muscle, skeletal muscle, tongue).
DR MIM; 610692; gene.
DR neXtProt; NX_Q9UBY9; -.
DR OpenTargets; ENSG00000173641; -.
DR PharmGKB; PA29514; -.
DR VEuPathDB; HostDB:ENSG00000173641; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00390000010674; -.
DR HOGENOM; CLU_124226_0_0_1; -.
DR InParanoid; Q9UBY9; -.
DR OMA; DPPMDKA; -.
DR OrthoDB; 915847at2759; -.
DR PhylomeDB; Q9UBY9; -.
DR TreeFam; TF350564; -.
DR PathwayCommons; Q9UBY9; -.
DR SignaLink; Q9UBY9; -.
DR BioGRID-ORCS; 27129; 12 hits in 1070 CRISPR screens.
DR ChiTaRS; HSPB7; human.
DR GenomeRNAi; 27129; -.
DR Pharos; Q9UBY9; Tbio.
DR PRO; PR:Q9UBY9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9UBY9; protein.
DR Bgee; ENSG00000173641; Expressed in left ventricle myocardium and 135 other tissues.
DR ExpressionAtlas; Q9UBY9; baseline and differential.
DR Genevisible; Q9UBY9; HS.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0016235; C:aggresome; IDA:HPA.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0031005; F:filamin binding; IEA:Ensembl.
DR GO; GO:0008022; F:protein C-terminus binding; TAS:ProtInc.
DR GO; GO:0007507; P:heart development; IEA:InterPro.
DR GO; GO:0008016; P:regulation of heart contraction; TAS:ProtInc.
DR GO; GO:0006986; P:response to unfolded protein; TAS:ProtInc.
DR CDD; cd06479; ACD_HspB7_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR037885; ACD_HspB7.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chaperone; Cytoplasm; Nucleus; Reference proteome;
KW Stress response.
FT CHAIN 1..170
FT /note="Heat shock protein beta-7"
FT /id="PRO_0000125941"
FT DOMAIN 62..170
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT REGION 1..71
FT /note="Required for localization to SC35 splicing speckles"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 67
FT /note="A -> AAHPTA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10593960,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_002424"
FT VAR_SEQ 68
FT /note="R -> K (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10593960"
FT /id="VSP_002425"
FT VAR_SEQ 69..170
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10593960"
FT /id="VSP_002426"
SQ SEQUENCE 170 AA; 18611 MW; 0A6F47931AE67B3E CRC64;
MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD DFGSFMRPHS
EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT SNNHIEVRAE KLAADGTVMN
TFAHKCQLPE DVDPTSVTSA LREDGSLTIR ARRHPHTEHV QQTFRTEIKI
