ID   HSPB7_RAT               Reviewed;          90 AA.
AC   Q9QUK5;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Heat shock protein beta-7;
DE            Short=HspB7;
DE   AltName: Full=Cardiovascular heat shock protein;
DE            Short=cvHsp;
DE   Flags: Fragment;
GN   Name=Hspb7; Synonyms=Cvhsp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=10593960; DOI=10.1074/jbc.274.51.36592;
RA   Krief S., Faivre J.-F., Robert P., Le Douarin B., Brument-Larignon N.,
RA   Lefrere I., Bouzyk M.M., Anderson K.M., Greller L.D., Tobin F.L.,
RA   Souchet M., Bril A.;
RT   "Identification and characterization of cvHsp. A novel human small stress
RT   protein selectively expressed in cardiovascular and insulin-sensitive
RT   tissues.";
RL   J. Biol. Chem. 274:36592-36600(1999).
CC   -!- SUBUNIT: Interacts with C-terminal domain of actin-binding protein 280.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Nucleus, Cajal body {ECO:0000250}. Note=Resides in sub-nuclear
CC       structures known as SC35 speckles or nuclear splicing speckles.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Found in both cardiac and skeletal muscle.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; AJ243193; CAB63268.1; -; mRNA.
DR   EMBL; AF155910; AAF20024.1; -; mRNA.
DR   AlphaFoldDB; Q9QUK5; -.
DR   STRING; 10116.ENSRNOP00000042240; -.
DR   PaxDb; Q9QUK5; -.
DR   PRIDE; Q9QUK5; -.
DR   UCSC; RGD:62021; rat.
DR   RGD; 62021; Hspb7.
DR   eggNOG; KOG3591; Eukaryota.
DR   InParanoid; Q9QUK5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0015629; C:actin cytoskeleton; ISO:RGD.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0031005; F:filamin binding; ISO:RGD.
DR   GO; GO:0009408; P:response to heat; IDA:RGD.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   Pfam; PF00011; HSP20; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Nucleus; Reference proteome; Stress response.
FT   CHAIN           <1..>90
FT                   /note="Heat shock protein beta-7"
FT                   /id="PRO_0000125943"
FT   DOMAIN          39..>90
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   NON_TER         1
FT   NON_TER         90
SQ   SEQUENCE   90 AA;  9804 MW;  9D122DB6443ED1FE CRC64;
     SSSSSSASRA LPAQDPPMEK ALSMFSEDFG SFMLPHSEPL TFPARPGGQG NIKTLGDAYE
     FTVDMRDFSP EDIIVTTSNN HIEVRAEKKP