HSPB8_MACMU
ID HSPB8_MACMU Reviewed; 195 AA.
AC Q6SJQ8;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Heat shock protein beta-8;
DE Short=HspB8;
DE AltName: Full=Protein kinase H11;
GN Name=HSPB8;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li F.-X., Sun X.-Y., Liu J., Tang S., Wang Y.-L.;
RT "Cloning and expression of protein kinase H11 gene in Rhesus monkey (Macaca
RT mulatta) uterine endometrium.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Displays temperature-dependent chaperone activity.
CC {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Interacts with HSPB1 (By similarity). Interacts with
CC DNAJB6 (By similarity). Interacts with BAG3 (By similarity).
CC {ECO:0000250|UniProtKB:Q9UJY1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UJY1}. Nucleus
CC {ECO:0000250|UniProtKB:Q9UJY1}. Note=Translocates to nuclear foci
CC during heat shock. {ECO:0000250|UniProtKB:Q9UJY1}.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; AY457046; AAR20447.1; -; mRNA.
DR RefSeq; NP_001028109.1; NM_001032937.1.
DR AlphaFoldDB; Q6SJQ8; -.
DR SMR; Q6SJQ8; -.
DR STRING; 9544.ENSMMUP00000027956; -.
DR GeneID; 574341; -.
DR KEGG; mcc:574341; -.
DR CTD; 26353; -.
DR eggNOG; KOG3591; Eukaryota.
DR InParanoid; Q6SJQ8; -.
DR OrthoDB; 1187096at2759; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0101031; C:chaperone complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR CDD; cd06480; ACD_HspB8_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR043254; HSPB8.
DR InterPro; IPR042790; HspB8_ACD.
DR PANTHER; PTHR46906; PTHR46906; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Cytoplasm; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Stress response.
FT CHAIN 1..195
FT /note="Heat shock protein beta-8"
FT /id="PRO_0000125946"
FT DOMAIN 73..184
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT REGION 175..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9EPX0"
FT MOD_RES 62
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UJY1"
FT MOD_RES 70
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9JK92"
FT MOD_RES 77
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9JK92"
SQ SEQUENCE 195 AA; 21358 MW; 905B548A7693C73C CRC64;
MADGQMPFSC HYPSRLRRDP SGLSLSSRLL DDGFGMDPFP DDLTASWPDW ALPRLSSAWP
GTLRSGMVPR GPTATARFGV PAEGRTPPPF PGEPWKVCVN VHSFKPEELM VKIKDGYVEV
SGKHEEKQQE GGIVSKNFTK KIQLPAEVDP VTVFASLSPE GLLIIEAPQV PPYSTFGESS
FNNELPQDSQ EVTCT
