ID   HSPB8_PONAB             Reviewed;         196 AA.
AC   Q5RAB0; Q5RDB3;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Heat shock protein beta-8;
DE            Short=HspB8;
GN   Name=HSPB8;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Displays temperature-dependent chaperone activity.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with HSPB1 (By similarity). Interacts with
CC       DNAJB6 (By similarity). Interacts with BAG3 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9UJY1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UJY1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UJY1}. Note=Translocates to nuclear foci
CC       during heat shock. {ECO:0000250|UniProtKB:Q9UJY1}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; CR858001; CAH90244.1; -; mRNA.
DR   EMBL; CR859108; CAH91300.1; -; mRNA.
DR   RefSeq; NP_001127400.1; NM_001133928.1.
DR   RefSeq; NP_001128773.1; NM_001135301.1.
DR   AlphaFoldDB; Q5RAB0; -.
DR   SMR; Q5RAB0; -.
DR   Ensembl; ENSPPYT00000049540; ENSPPYP00000031943; ENSPPYG00000041725.
DR   GeneID; 100174469; -.
DR   GeneID; 100189671; -.
DR   KEGG; pon:100174469; -.
DR   CTD; 26353; -.
DR   GeneTree; ENSGT00940000160605; -.
DR   InParanoid; Q5RAB0; -.
DR   OrthoDB; 1187096at2759; -.
DR   Proteomes; UP000001595; Chromosome 12.
DR   GO; GO:0101031; C:chaperone complex; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0034620; P:cellular response to unfolded protein; IEA:Ensembl.
DR   GO; GO:1905337; P:positive regulation of aggrephagy; IEA:Ensembl.
DR   CDD; cd06480; ACD_HspB8_like; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR043254; HSPB8.
DR   InterPro; IPR042790; HspB8_ACD.
DR   PANTHER; PTHR46906; PTHR46906; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Methylation; Nucleus; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..196
FT                   /note="Heat shock protein beta-8"
FT                   /id="PRO_0000125948"
FT   DOMAIN          74..185
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   REGION          176..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UJY1"
FT   MOD_RES         57
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9EPX0"
FT   MOD_RES         63
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UJY1"
FT   MOD_RES         71
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK92"
FT   MOD_RES         78
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK92"
FT   CONFLICT        116
FT                   /note="D -> G (in Ref. 1; CAH90244)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   196 AA;  21604 MW;  B76058CED52292CB CRC64;
     MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD WALPRLSSAW
     PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV NVHSFKPEEL MVKTKDGYVE
     VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD PVTVFASLSP EGLLIIEAPQ VPPYSTFGES
     SFNNELPQDS QEVTCT