HSPB9_HUMAN
ID HSPB9_HUMAN Reviewed; 159 AA.
AC Q9BQS6; B3KSG6; Q52LB4;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Heat shock protein beta-9;
DE Short=HspB9;
DE AltName: Full=Cancer/testis antigen 51;
DE Short=CT51;
GN Name=HSPB9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=11470154; DOI=10.1016/s0167-4781(01)00237-8;
RA Kappe G., Verschuure P., Philipsen R.L.A., Staalduinen A.A.,
RA Van de Boogaart P., Boelens W.C., de Jong W.W.;
RT "Characterization of two novel human small heat shock proteins: protein
RT kinase-related HspB8 and testis-specific HspB9.";
RL Biochim. Biophys. Acta 1520:1-6(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=19464326; DOI=10.1016/j.bbamcr.2009.05.005;
RA Vos M.J., Kanon B., Kampinga H.H.;
RT "HSPB7 is a SC35 speckle resident small heat shock protein.";
RL Biochim. Biophys. Acta 1793:1343-1353(2009).
CC -!- INTERACTION:
CC Q9BQS6; P63172: DYNLT1; NbExp=5; IntAct=EBI-1176448, EBI-1176455;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus
CC {ECO:0000269|PubMed:19464326}. Note=Translocates to nuclear foci during
CC heat shock.
CC -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:11470154}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; AJ302068; CAC35727.1; -; Genomic_DNA.
DR EMBL; AK093488; BAG52728.1; -; mRNA.
DR EMBL; CH471152; EAW60804.1; -; Genomic_DNA.
DR EMBL; BC093991; AAH93991.1; -; mRNA.
DR EMBL; BC093993; AAH93993.1; -; mRNA.
DR CCDS; CCDS11418.1; -.
DR RefSeq; NP_149971.1; NM_033194.2.
DR AlphaFoldDB; Q9BQS6; -.
DR SMR; Q9BQS6; -.
DR BioGRID; 125108; 24.
DR IntAct; Q9BQS6; 13.
DR STRING; 9606.ENSP00000458018; -.
DR PhosphoSitePlus; Q9BQS6; -.
DR BioMuta; HSPB9; -.
DR DMDM; 46576635; -.
DR PaxDb; Q9BQS6; -.
DR PeptideAtlas; Q9BQS6; -.
DR PRIDE; Q9BQS6; -.
DR Antibodypedia; 59368; 89 antibodies from 22 providers.
DR DNASU; 94086; -.
DR Ensembl; ENST00000565659.2; ENSP00000458018.1; ENSG00000260325.2.
DR GeneID; 94086; -.
DR KEGG; hsa:94086; -.
DR MANE-Select; ENST00000565659.2; ENSP00000458018.1; NM_033194.3; NP_149971.1.
DR UCSC; uc002hyy.3; human.
DR CTD; 94086; -.
DR DisGeNET; 94086; -.
DR GeneCards; HSPB9; -.
DR HGNC; HGNC:30589; HSPB9.
DR HPA; ENSG00000260325; Tissue enhanced (testis).
DR MIM; 608344; gene.
DR neXtProt; NX_Q9BQS6; -.
DR OpenTargets; ENSG00000260325; -.
DR PharmGKB; PA134875756; -.
DR VEuPathDB; HostDB:ENSG00000260325; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00510000049735; -.
DR HOGENOM; CLU_1585932_0_0_1; -.
DR InParanoid; Q9BQS6; -.
DR OMA; TAMTCCL; -.
DR OrthoDB; 1483856at2759; -.
DR PhylomeDB; Q9BQS6; -.
DR TreeFam; TF338684; -.
DR PathwayCommons; Q9BQS6; -.
DR SignaLink; Q9BQS6; -.
DR BioGRID-ORCS; 94086; 12 hits in 1062 CRISPR screens.
DR GenomeRNAi; 94086; -.
DR Pharos; Q9BQS6; Tbio.
DR PRO; PR:Q9BQS6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BQS6; protein.
DR Bgee; ENSG00000260325; Expressed in left testis and 97 other tissues.
DR Genevisible; Q9BQS6; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR042940; HSPB9.
DR PANTHER; PTHR47896; PTHR47896; 1.
DR Pfam; PF00011; HSP20; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Stress response.
FT CHAIN 1..159
FT /note="Heat shock protein beta-9"
FT /id="PRO_0000125950"
FT DOMAIN 36..147
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT VARIANT 2
FT /note="Q -> P (in dbSNP:rs1122326)"
FT /id="VAR_022054"
SQ SEQUENCE 159 AA; 17486 MW; F28E40D0512C4997 CRC64;
MQRVGNTFSN ESRVASRCPS VGLAERNRVA TMPVRLLRDS PAAQEDNDHA RDGFQMKLDA
HGFAPEELVV QVDGQWLMVT GQQQLDVRDP ERVSYRMSQK VHRKMLPSNL SPTAMTCCLT
PSGQLWVRGQ CVALALPEAQ TGPSPRLGSL GSKASNLTR
