HSPB9_MOUSE
ID HSPB9_MOUSE Reviewed; 168 AA.
AC Q9DAM3; A2A5F2;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Heat shock protein beta-9;
DE Short=HspB9;
GN Name=Hspb9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=11470154; DOI=10.1016/s0167-4781(01)00237-8;
RA Kappe G., Verschuure P., Philipsen R.L.A., Staalduinen A.A.,
RA Van de Boogaart P., Boelens W.C., de Jong W.W.;
RT "Characterization of two novel human small heat shock proteins: protein
RT kinase-related HspB8 and testis-specific HspB9.";
RL Biochim. Biophys. Acta 1520:1-6(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Translocates to nuclear foci during heat shock. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:11470154}.
CC -!- DEVELOPMENTAL STAGE: Expressed notably in the spermatogenic cells from
CC late pachytene spermatocyte stage till elongate spermatid stage.
CC {ECO:0000269|PubMed:11470154}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; AJ302069; CAC35730.1; -; Genomic_DNA.
DR EMBL; AK005714; BAB24201.1; -; mRNA.
DR EMBL; AL591469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48932.2; -.
DR RefSeq; NP_083583.1; NM_029307.1.
DR AlphaFoldDB; Q9DAM3; -.
DR SMR; Q9DAM3; -.
DR IntAct; Q9DAM3; 1.
DR STRING; 10090.ENSMUSP00000130551; -.
DR iPTMnet; Q9DAM3; -.
DR PhosphoSitePlus; Q9DAM3; -.
DR PaxDb; Q9DAM3; -.
DR PRIDE; Q9DAM3; -.
DR ProteomicsDB; 273282; -.
DR Antibodypedia; 59368; 89 antibodies from 22 providers.
DR Ensembl; ENSMUST00000017976; ENSMUSP00000017976; ENSMUSG00000017832.
DR GeneID; 75482; -.
DR KEGG; mmu:75482; -.
DR CTD; 94086; -.
DR MGI; MGI:1922732; Hspb9.
DR VEuPathDB; HostDB:ENSMUSG00000017832; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00510000049735; -.
DR InParanoid; Q9DAM3; -.
DR OrthoDB; 1483856at2759; -.
DR PhylomeDB; Q9DAM3; -.
DR BioGRID-ORCS; 75482; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Hspb9; mouse.
DR PRO; PR:Q9DAM3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DAM3; protein.
DR Bgee; ENSMUSG00000017832; Expressed in seminiferous tubule of testis and 31 other tissues.
DR ExpressionAtlas; Q9DAM3; baseline and differential.
DR Genevisible; Q9DAM3; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR042940; HSPB9.
DR PANTHER; PTHR47896; PTHR47896; 1.
DR Pfam; PF00011; HSP20; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Stress response.
FT CHAIN 1..168
FT /note="Heat shock protein beta-9"
FT /id="PRO_0000125951"
FT DOMAIN 38..151
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 168 AA; 18493 MW; 7A77ED458F31D315 CRC64;
MQRVGSSFST GQREPGENRV ASRCPSVALA ERNQVATLPV RLLRDEVQGN GCEQPSFQIK
VDAQGFAPED LVVRIDGQNL TVTGQRQHES NDPSRGRYRM EQSVHRQMQL PPTLDPAAMT
CSLTPSGHLW LRGQNKCLPP PEAQTGQSQK PRRGGPKSSL QNESVKNP
