ID   HSPR_STRCO              Reviewed;         151 AA.
AC   P40183;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Putative heat shock protein HspR;
GN   Name=hspR; OrderedLocusNames=SCO3668; ORFNames=SCH44.08c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=8801421; DOI=10.1111/j.1365-2958.1995.mmi_17040663.x;
RA   Bucca G., Ferina G., Puglia A.M., Smith C.P.;
RT   "The dnaK operon of Streptomyces coelicolor encodes a novel heat-shock
RT   protein which binds to the promoter region of the operon.";
RL   Mol. Microbiol. 17:663-674(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Binds to three inverted repeats (IR1-IR3) in the promoter
CC       region of the dnaK operon.
CC   -!- INDUCTION: By heat shock.
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DR   EMBL; L46700; AAB29454.1; -; Genomic_DNA.
DR   EMBL; AL939117; CAB91159.1; -; Genomic_DNA.
DR   PIR; S70209; S70209.
DR   RefSeq; NP_627861.1; NC_003888.3.
DR   RefSeq; WP_003975271.1; NZ_VNID01000003.1.
DR   AlphaFoldDB; P40183; -.
DR   SMR; P40183; -.
DR   STRING; 100226.SCO3668; -.
DR   GeneID; 1099104; -.
DR   KEGG; sco:SCO3668; -.
DR   PATRIC; fig|100226.15.peg.3726; -.
DR   eggNOG; COG0789; Bacteria.
DR   HOGENOM; CLU_060077_7_1_11; -.
DR   InParanoid; P40183; -.
DR   OMA; GRRYSEH; -.
DR   PhylomeDB; P40183; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:CACAO.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..151
FT                   /note="Putative heat shock protein HspR"
FT                   /id="PRO_0000098127"
FT   DOMAIN          17..86
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   151 AA;  16939 MW;  A0675EB251CCD4EC CRC64;
     MDGRRRNPYE LTEDTPVYVI SVAAQLSGLH PQTLRQYDRL GLVSPDRTAG RGRRYSARDI
     ELLRQVQQLS QDEGINLAGI KRIIELENQV AELQARAAEL AAALDGAATA MRQREAAVHA
     SYRRDLVPYQ EVQQTSALVV WRPSRRGQSS D