HSR1_SCHPO
ID HSR1_SCHPO Reviewed; 582 AA.
AC Q10076;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Hydrogen peroxide stress regulator 1;
GN Name=hsr1; ORFNames=SPAC3H1.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=18003976; DOI=10.1091/mbc.e07-08-0735;
RA Chen D., Wilkinson C.R., Watt S., Penkett C.J., Toone W.M., Jones N.,
RA Bahler J.;
RT "Multiple pathways differentially regulate global oxidative stress
RT responses in fission yeast.";
RL Mol. Biol. Cell 19:308-317(2008).
CC -!- FUNCTION: Transcription factor that globally supports gene expression
CC in response to hydrogen peroxide. {ECO:0000269|PubMed:18003976}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- INDUCTION: Expression is induced by hydrogen peroxide, and this
CC induction requires prr1 and pap1p as well as atf1p and sty1p.
CC {ECO:0000269|PubMed:18003976}.
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DR EMBL; CU329670; CAA92264.1; -; Genomic_DNA.
DR PIR; T38743; T38743.
DR RefSeq; NP_593553.1; NM_001018986.2.
DR AlphaFoldDB; Q10076; -.
DR BioGRID; 279679; 5.
DR STRING; 4896.SPAC3H1.11.1; -.
DR iPTMnet; Q10076; -.
DR MaxQB; Q10076; -.
DR PaxDb; Q10076; -.
DR PRIDE; Q10076; -.
DR EnsemblFungi; SPAC3H1.11.1; SPAC3H1.11.1:pep; SPAC3H1.11.
DR GeneID; 2543251; -.
DR KEGG; spo:SPAC3H1.11; -.
DR PomBase; SPAC3H1.11; hsr1.
DR VEuPathDB; FungiDB:SPAC3H1.11; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_468648_0_0_1; -.
DR InParanoid; Q10076; -.
DR OMA; VAMQPLY; -.
DR PhylomeDB; Q10076; -.
DR PRO; PR:Q10076; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; ISM:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:PomBase.
DR GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IMP:PomBase.
DR GO; GO:0042594; P:response to starvation; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..582
FT /note="Hydrogen peroxide stress regulator 1"
FT /id="PRO_0000046865"
FT ZN_FING 423..446
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..473
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 24..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 64126 MW; D325324E522E1B8D CRC64;
MVFFPEAMPL VTLSERMVPQ VNTSPFAPAQ SSSPLPSNSC REYSLPSHPS THNSSVAYVD
SQDNKPPLVS TLHFSLAPSL SPSSAQSHNT ALITEPLTSF IGGTSQYPSA SFSTSQHPSQ
VYNDGSTLNS NNTTQQLNNN NGFQPPPQNP GISKSRIAQY HQPSQTYDDT VDSSFYDWYK
AGAQHNLAPP QSSHTEASQG YMYSTNTAHD ATDIPSSFNF YNTQASTAPN PQEINYQWSH
EYRPHTQYQN NLLRAQPNVN CENFPTTVPN YPFQQPSYNP NALVPSYTTL VSQLPPSPCL
TVSSGPLSTA SSIPSNCSCP SVKSSGPSYH AEQEVNVNSY NGGIPSTSYN DTPQQSVTGS
YNSGETMSTY LNQTNTSGRS PNSMEATEQI GTIGTDGSMK RRKRRQPSNR KTSVPRSPGG
KSFVCPECSK KFKRSEHLRR HIRSLHTSEK PFVCICGKRF SRRDNLRQHE RLHVNASPRL
ACFFQPSGYY SSGAPGAPVQ PQKPIEDLNK IPINQGMDSS QIENTNLMLS SQRPLSQQIV
PEIAAYPNSI RPELLSKLPV QTPNQKMPLM NPMHQYQPYP SS
