HSR9_CAEEL
ID HSR9_CAEEL Reviewed; 1165 AA.
AC Q7JKP6;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein hsr-9 {ECO:0000305};
DE AltName: Full=Heat shock related protein 9 {ECO:0000305};
DE AltName: Full=Tumor suppressor p53-binding protein 1 homolog {ECO:0000303|PubMed:23667696};
DE Short=53BP1 {ECO:0000303|PubMed:23667696};
GN Name=hsr-9 {ECO:0000312|WormBase:T05F1.6};
GN ORFNames=T05F1.6 {ECO:0000312|WormBase:T05F1.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=23667696; DOI=10.1371/journal.pone.0064028;
RA Ryu J.S., Kang S.J., Koo H.S.;
RT "The 53BP1 homolog in C. elegans influences DNA repair and promotes
RT apoptosis in response to ionizing radiation.";
RL PLoS ONE 8:E64028-E64028(2013).
CC -!- FUNCTION: May have a role in DNA double-strand break repair following
CC gamma-irradiation. {ECO:0000269|PubMed:23667696}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23667696}.
CC Note=Localized to the nuclei of proliferating germ cells.
CC {ECO:0000269|PubMed:23667696}.
CC -!- TISSUE SPECIFICITY: Expressed in germ cells.
CC {ECO:0000269|PubMed:23667696}.
CC -!- INDUCTION: Induced by DNA damage cues including gamma-irradiation, and
CC UV and hydroxyurea treatment. {ECO:0000269|PubMed:23667696}.
CC -!- DISRUPTION PHENOTYPE: Reduced number of apoptotic cells following
CC gamma-irradiation. In a rad-54 knockdown but not in brc-1 mutant
CC background, restores levels of embryonic survival and chromosomal
CC aberrations in oocytes following gamma-irradiation to almost wildtype.
CC Mutants show slightly reduced levels of egl-1 mRNA expression.
CC {ECO:0000269|PubMed:23667696}.
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DR EMBL; BX284601; CAF31485.1; -; Genomic_DNA.
DR RefSeq; NP_001021610.1; NM_001026439.2.
DR AlphaFoldDB; Q7JKP6; -.
DR SMR; Q7JKP6; -.
DR STRING; 6239.T05F1.6; -.
DR EPD; Q7JKP6; -.
DR PaxDb; Q7JKP6; -.
DR PeptideAtlas; Q7JKP6; -.
DR PRIDE; Q7JKP6; -.
DR EnsemblMetazoa; T05F1.6.1; T05F1.6.1; WBGene00002027.
DR GeneID; 3565010; -.
DR KEGG; cel:CELE_T05F1.6; -.
DR UCSC; T05F1.6; c. elegans.
DR CTD; 3565010; -.
DR WormBase; T05F1.6; CE36405; WBGene00002027; hsr-9.
DR eggNOG; KOG3548; Eukaryota.
DR GeneTree; ENSGT00390000011891; -.
DR HOGENOM; CLU_277883_0_0_1; -.
DR InParanoid; Q7JKP6; -.
DR OMA; LWDRLYY; -.
DR OrthoDB; 674207at2759; -.
DR PRO; PR:Q7JKP6; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002027; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.40.50.10190; -; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR Pfam; PF00533; BRCT; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; SSF52113; 2.
DR PROSITE; PS50172; BRCT; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..1165
FT /note="Protein hsr-9"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437442"
FT DOMAIN 923..1028
FT /note="BRCT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..176
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..227
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 127607 MW; B05655BA39867A89 CRC64;
MASSSNTMEF EEDDSTVTQT SLPTTTSVLD KSRSLFGNSA VISTPARDST PDGHIVDSSV
ITKSSVIIEA EDEPDVAADV TALDKEKAED EPQCSAGKDA KSGESMNDSE KSESPIEEGE
GETFEKKIIS MDTSDDKLDI AESISVSNDT EKPEENEEKV VGDEDEEDID DVQEDDEDEA
PKKKTKKAVS TSDDDDLHED DSPKGGSVSD EKEEPENEDD TEEPENEVEV ESPVKEQADS
GEPIENVNDD KASEPGVGEI SQDSVDDSQK IGLDSKSPDG ESEANEENQE SQSSSRSTRR
AKRVSATVSS TPSSNTPRRG GRGQKSEVNA DETKTPIVSN STPRRGRSSR GGDRDEVIDP
TENVVGDSGV EETSPRKGRS RRSVATEDTS VTEEVENTEH PTEEETPKQG RGRRSAASSS
ATSSAVPTPR STRGRGRKSQ ANEENLQEKE TEDPTKTHDT NQAKSTRTPR GRRSNADAET
MESVEAEKVE TPTSSRRSTR AKPPAKSAPV TPAVTNKRTT VRGRKKQGSI TEDPIEEADE
TIEETLPQKK GRGAAKSAPS SSKKSAEYDP YDLDTEMEHH PEPLKNIHME VHNFGAVKYA
KLGNSESKYS MTEKAAESRI AELQSSPAAK NRRSLADMTP GKDKMKHRVS SVGTSGRRSR
AKKEEEHHEN DIEMEDAPAT ATPASSNRGR KRKSEASDIK TPPAKKEPVI PLKNLSDEDQ
LLVDHPQDDN EPHAPGARVY AVFQKMFYPA VVLSERDGLG RYKVQFTVDN VIKDVPNSGI
IPLRALSPGK TAVYNESDVR LDSGPNDISA AEWKKGKLTI SIMDEDGEPT DEVKVVDWYD
VSFDHSEWRD YVKSKDQSAT AIVTSNITTI SEATRARKPT TVSNQAKPKG RKKKGVDLVS
SRGGSASPAE EEEKLLPMNE EAIGKNIFTG KVFMLTSANR SNSASVPSMF KKKNLMNFIT
QNGGIVTEQL NSFQERYSNY EPLLISDTYY RTHKYLAALA RGVPCVNNTW LQACGEQGKC
VDYTDYVLPA GASIFDESQD MPAPKNPSEL LKGTTIYVHS THSAREVTQT GPGGTFIEIW
KPILELLGAD VVDGDWETLD ETGLKFDVVL VDGTFRDEVM EYADTIGASR VTSEWVIQTI
ILGKAPEPNA HPKFDPYRLH HRTRH
