ID   HSRA_HAEIN              Reviewed;         463 AA.
AC   P44903;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Probable transport protein HsrA;
GN   Name=hsrA; OrderedLocusNames=HI_0852;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22509.1; -; Genomic_DNA.
DR   PIR; B64160; B64160.
DR   RefSeq; NP_439012.1; NC_000907.1.
DR   RefSeq; WP_010869070.1; NC_000907.1.
DR   AlphaFoldDB; P44903; -.
DR   SMR; P44903; -.
DR   STRING; 71421.HI_0852; -.
DR   EnsemblBacteria; AAC22509; AAC22509; HI_0852.
DR   KEGG; hin:HI_0852; -.
DR   PATRIC; fig|71421.8.peg.893; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_000960_28_0_6; -.
DR   OMA; DFRWAFV; -.
DR   PhylomeDB; P44903; -.
DR   BioCyc; HINF71421:G1GJ1-892-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..463
FT                   /note="Probable transport protein HsrA"
FT                   /id="PRO_0000173410"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   463 AA;  50003 MW;  D725EFFD50F9F23F CRC64;
     MTTESNAYRG LAWVAAMALF MQSLDATILN TALPAISSDL HKPAFEMQMA IIAYSLAVAL
     FIPLTAWAAA KFGTLTVFRS AVFTFILGSV ACAAASNLES LILARVIQGI GGAFMMPVAR
     LAIIQAVPKQ QLVNAWNLMA TAGLIGPILG PILGGWLVIH ASWHWIFLIN IPIGALGILA
     SGSVMNNIKG KAEKLDWTGF LLFALGLVGI TLGLDLLGES QHNSSVTYSI LVVGILLLVT
     YCGYAKNNEN AILPLSLFRT RTFRLGIIAN IFIRLSASGV PFLLPLMFQL SFGYSAEMSG
     WLLAPIALIS VMLKILIGRI LNRWGYKTTL ISSALLMAGS VISMAWLDKQ SSLTWIICNL
     MWYGACMSII FTSINTLAVG DLSKQQSGTG STVLSIVQQV GIGFGIAVSS IILNLYRHFF
     SASDCLPQAF SYTFLTSSLF VIALVWSLMK LHKHDGDHLR KMP