HSSR_STAHJ
ID HSSR_STAHJ Reviewed; 224 AA.
AC Q4L8L9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Heme response regulator HssR;
GN Name=hssR; OrderedLocusNames=SH0697;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- FUNCTION: Member of the two-component regulatory system HssS/HssR
CC involved in intracellular heme homeostasis and tempering of
CC staphylococcal virulence. Phosphorylated HssR binds to a direct repeat
CC sequence within hrtAB promoter and activates the expression of hrtAB,
CC an efflux pump, in response to extracellular heme, hemin, hemoglobin or
CC blood (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by HssS. {ECO:0000250}.
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DR EMBL; AP006716; BAE04006.1; -; Genomic_DNA.
DR RefSeq; WP_011275022.1; NC_007168.1.
DR AlphaFoldDB; Q4L8L9; -.
DR SMR; Q4L8L9; -.
DR STRING; 279808.SH0697; -.
DR EnsemblBacteria; BAE04006; BAE04006; SH0697.
DR GeneID; 58063114; -.
DR KEGG; sha:SH0697; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_3_9; -.
DR OMA; KYLMSHP; -.
DR OrthoDB; 817710at2; -.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system; Virulence.
FT CHAIN 1..224
FT /note="Heme response regulator HssR"
FT /id="PRO_0000331335"
FT DOMAIN 3..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 124..222
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 52
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 224 AA; 25823 MW; 96D6C35992D0E913 CRC64;
MVKCLIVDDD YKILHYVSQH LEAAQIQTVT QASGESAIAY LANNKVDIAV VDIMMTGMDG
FELCQLLKND YDLPVIMLTA RDALSDKERA FVSGTDDYVT KPFEVKELLF RIQAVLRRYQ
INSQDIIKLG NVTLIQEYME LSVDSKNVNL PTKEFQLLFL LCGQPKHIFT RDTLIERIWG
FDYEGDERTI DVHIKRLRHR LNQLKATIEI QTVRGQGYRV ITHV
