HSSR_STAS1
ID HSSR_STAS1 Reviewed; 224 AA.
AC Q49ZT8;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Heme response regulator HssR;
GN Name=hssR; OrderedLocusNames=SSP0541;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: Member of the two-component regulatory system HssS/HssR
CC involved in intracellular heme homeostasis and tempering of
CC staphylococcal virulence. Phosphorylated HssR binds to a direct repeat
CC sequence within hrtAB promoter and activates the expression of hrtAB,
CC an efflux pump, in response to extracellular heme, hemin, hemoglobin or
CC blood (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by HssS. {ECO:0000250}.
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DR EMBL; AP008934; BAE17686.1; -; Genomic_DNA.
DR RefSeq; WP_002482492.1; NZ_MTGA01000036.1.
DR AlphaFoldDB; Q49ZT8; -.
DR SMR; Q49ZT8; -.
DR STRING; 342451.SSP0541; -.
DR EnsemblBacteria; BAE17686; BAE17686; SSP0541.
DR GeneID; 66866692; -.
DR KEGG; ssp:SSP0541; -.
DR PATRIC; fig|342451.11.peg.545; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_3_9; -.
DR OMA; WQQSYGD; -.
DR OrthoDB; 817710at2; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system;
KW Virulence.
FT CHAIN 1..224
FT /note="Heme response regulator HssR"
FT /id="PRO_0000331336"
FT DOMAIN 3..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 124..222
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 52
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 224 AA; 25861 MW; BCCF6641D207C6DF CRC64;
MTTCLIVDDD PKILEYVSKY IEREHFETIV QSSAENALSY LETHQVDIAI VDVMMGKMSG
FELCKILKED FDIPVIMLTA RDALSDKEQA YLTGTDDYVT KPFEVKELMF RIKAVLKRYN
VNINNEVSIG NLTLNQSYLE IQSSSKSMNL PNKEFQLLFL LASNPRQVFN RDALIEKIWG
FDYEGDERTV DVHIKRLRKR LEKIDASVTI HTVRGLGYKV DDHV
