ID   HST2_ECOLX              Reviewed;          72 AA.
AC   Q47185;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Heat-stable enterotoxin A2;
DE            Short=STA2;
DE   Flags: Precursor;
GN   Name=sta2;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2643580; DOI=10.1128/iai.57.2.645-648.1989;
RA   Guzman-Verduzio L.M., Kupersztoch Y.M.;
RT   "Rectification of two Escherichia coli heat-stable enterotoxin allele
RT   sequences and lack of biological effect of changing the carboxy-terminal
RT   tyrosine to histidine.";
RL   Infect. Immun. 57:645-648(1989).
CC   -!- FUNCTION: Toxin which activates the particulate form of guanylate
CC       cyclase and increases cyclic GMP levels within the host intestinal
CC       epithelial cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heat-stable enterotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; M18345; AAA23729.1; -; Genomic_DNA.
DR   PIR; JS0292; QHECIB.
DR   RefSeq; WP_014654027.1; NZ_UEMW01000095.1.
DR   AlphaFoldDB; Q47185; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019806; Heat-stable_enterotox_CS.
DR   InterPro; IPR001489; Heat-stable_enterotox_STa.
DR   Pfam; PF02048; Enterotoxin_ST; 1.
DR   PROSITE; PS00273; ENTEROTOXIN_H_STABLE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Enterotoxin; Secreted; Signal; Toxin; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..53
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035128"
FT   PEPTIDE         54..72
FT                   /note="Heat-stable enterotoxin A2"
FT                   /id="PRO_0000035129"
FT   DISULFID        59..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        63..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   72 AA;  7895 MW;  D87850306E06B260 CRC64;
     MKKSILFIFL SVLSFSPFAQ DAKPAGSSKE KITLESKKCN IVKKNNESSP ESMNSSNYCC
     ELCCNPACTG CY