ID   HSTB_ECOLX              Reviewed;          18 AA.
AC   P01560;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Heat-stable enterotoxin ST-2;
DE            Short=ST-B;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=O42:K86:H37 / 18D / ETEC;
RX   PubMed=7021541; DOI=10.1016/s0021-9258(18)43339-x;
RA   Chan S.-K., Giannella R.A.;
RT   "Amino acid sequence of heat-stable enterotoxin produced by Escherichia
RT   coli pathogenic for man.";
RL   J. Biol. Chem. 256:7744-7746(1981).
RN   [2]
RP   SEQUENCE REVISION TO 11 AND 18.
RX   PubMed=3882570; DOI=10.1128/iai.47.3.834-836.1985;
RA   Thompson M.R., Giannella R.A.;
RT   "Revised amino acid sequence for a heat-stable enterotoxin produced by an
RT   Escherichia coli strain (18D) that is pathogenic for humans.";
RL   Infect. Immun. 47:834-836(1985).
RN   [3]
RP   DISULFIDE BONDS.
RX   PubMed=3552731; DOI=10.1016/0014-5793(87)80134-5;
RA   Shimonishi Y., Hidaka Y., Koizumi M., Hane M., Aimoto S., Takeda T.,
RA   Miwatani T., Takeda Y.;
RT   "Mode of disulfide bond formation of a heat-stable enterotoxin (STh)
RT   produced by a human strain of enterotoxigenic Escherichia coli.";
RL   FEBS Lett. 215:165-170(1987).
CC   -!- FUNCTION: Toxin which activates the particulate form of guanylate
CC       cyclase and increases cyclic GMP levels within the host intestinal
CC       epithelial cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heat-stable enterotoxin family.
CC       {ECO:0000305}.
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DR   PIR; A01823; QHEC2.
DR   AlphaFoldDB; P01560; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019806; Heat-stable_enterotox_CS.
DR   InterPro; IPR001489; Heat-stable_enterotox_STa.
DR   Pfam; PF02048; Enterotoxin_ST; 1.
DR   PROSITE; PS00273; ENTEROTOXIN_H_STABLE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Enterotoxin; Secreted; Toxin;
KW   Virulence.
FT   PEPTIDE         1..18
FT                   /note="Heat-stable enterotoxin ST-2"
FT                   /id="PRO_0000044885"
FT   DISULFID        5..10
FT                   /evidence="ECO:0000269|PubMed:3552731"
FT   DISULFID        6..14
FT                   /evidence="ECO:0000269|PubMed:3552731"
FT   DISULFID        9..17
FT                   /evidence="ECO:0000269|PubMed:3552731"
SQ   SEQUENCE   18 AA;  1978 MW;  D4D975F49D60064F CRC64;
     NTFYCCELCC NPACAGCY