ID   HSTB_YEREN              Reviewed;          71 AA.
AC   P74977;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Heat-stable enterotoxin B;
DE   AltName: Full=Y-STB;
DE   Flags: Precursor;
GN   Name=ystB;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=84-50 / Serotype O:5;
RX   PubMed=9344780; DOI=10.1006/mpat.1997.0146;
RA   Ramamurthy T., Yoshino K., Huang X., Nair G.B., Carniel E., Maruyama T.,
RA   Fukushima H., Takeda T.;
RT   "The novel heat-stable enterotoxin subtype gene (ystB) of Yersinia
RT   enterocolitica: nucleotide sequence and distribution of the yst genes.";
RL   Microb. Pathog. 23:189-200(1997).
CC   -!- FUNCTION: Toxin which activates the particulate form of guanylate
CC       cyclase and increases cyclic GMP levels within the host intestinal
CC       epithelial cells. Could play an important role in pathogenesis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heat-stable enterotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; D88145; BAA13544.1; -; Genomic_DNA.
DR   RefSeq; WP_019079716.1; NZ_NJFX02000001.1.
DR   AlphaFoldDB; P74977; -.
DR   GeneID; 67418716; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019806; Heat-stable_enterotox_CS.
DR   InterPro; IPR001489; Heat-stable_enterotox_STa.
DR   Pfam; PF02048; Enterotoxin_ST; 1.
DR   PROSITE; PS00273; ENTEROTOXIN_H_STABLE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Enterotoxin; Secreted; Signal;
KW   Toxin; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..52
FT                   /id="PRO_0000035139"
FT   PEPTIDE         53..71
FT                   /note="Heat-stable enterotoxin B"
FT                   /id="PRO_0000035140"
FT   DISULFID        59..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        63..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  7670 MW;  ED6E9F61ACDD4F50 CRC64;
     MKKIILALVL MLFSFCTLGQ ETASMHLDDT LSAPIAAEIN RKACDTQTPS PSEENDDWCC
     EVCCNPACAG C