ID   HSTC_YEREN              Reviewed;          72 AA.
AC   O50319;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Heat-stable enterotoxin C;
DE   AltName: Full=Y-STC;
DE   Flags: Precursor;
GN   Name=ystC;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=86-11;
RX   PubMed=9049998; DOI=10.1006/mpat.1996.0094;
RA   Huang X., Yoshino K., Nakao H., Takeda T.;
RT   "Nucleotide sequence of a gene encoding the novel Yersinia enterocolitica
RT   heat-stable enterotoxin that includes a pro-region-like sequence in its
RT   mature toxin molecule.";
RL   Microb. Pathog. 22:89-97(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-72.
RC   STRAIN=Serotype O:3;
RX   PubMed=7729521; DOI=10.1016/0014-5793(95)00267-d;
RA   Yoshino K., Takao T., Huang X., Murata H., Nakao H., Takeda T.,
RA   Shimonishi Y.;
RT   "Characterization of a highly toxic, large molecular size heat-stable
RT   enterotoxin produced by a clinical isolate of Yersinia enterocolitica.";
RL   FEBS Lett. 362:319-322(1995).
CC   -!- FUNCTION: Toxin which activates the particulate form of guanylate
CC       cyclase and increases cyclic GMP levels within the host intestinal
CC       epithelial cells. Highly toxic.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heat-stable enterotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; D63578; BAA23656.1; -; Genomic_DNA.
DR   PIR; S68705; S68705.
DR   AlphaFoldDB; O50319; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019806; Heat-stable_enterotox_CS.
DR   InterPro; IPR001489; Heat-stable_enterotox_STa.
DR   Pfam; PF02048; Enterotoxin_ST; 1.
DR   PROSITE; PS00273; ENTEROTOXIN_H_STABLE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Enterotoxin; Secreted; Signal;
KW   Toxin; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:7729521"
FT   PEPTIDE         20..72
FT                   /note="Heat-stable enterotoxin C"
FT                   /id="PRO_0000035141"
FT   DISULFID        60..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..72
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   72 AA;  7639 MW;  7C0D83893C2F981D CRC64;
     MKKIVFVLTL MLFSFGTLGQ ETASGQVGDV SSSTIATEVS EAECGTQSAT TQGENDWDWC
     CELCCNPACF GC