ID   HSTI_ECOLX              Reviewed;          71 AA.
AC   P22542;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Heat-stable enterotoxin II;
DE            Short=STII;
DE   AltName: Full=Enterotoxin B;
DE   AltName: Full=ST-B;
DE   Flags: Precursor;
GN   Name=stiI;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6352496; DOI=10.1128/iai.42.1.269-275.1983;
RA   Picken R.N., Mazaitis A.J., Maas W.K., Rey M., Heyneker H.;
RT   "Nucleotide sequence of the gene for heat-stable enterotoxin II of
RT   Escherichia coli.";
RL   Infect. Immun. 42:269-275(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=711;
RX   PubMed=6352495; DOI=10.1128/iai.42.1.264-268.1983;
RA   Lee C.H., Moseley S.L., Moon H.W., Whipp S.C., Gyles C.L., So M.;
RT   "Characterization of the gene encoding heat-stable toxin II and preliminary
RT   molecular epidemiological studies of enterotoxigenic Escherichia coli heat-
RT   stable toxin II producers.";
RL   Infect. Immun. 42:264-268(1983).
RN   [3]
RP   STRUCTURE BY NMR.
RX   PubMed=8528070; DOI=10.1002/pro.5560040907;
RA   Sukumar M., Rizo J., Wall M., Dreyfus L.A., Kupersztoch Y.M.,
RA   Gierasch L.M.;
RT   "The structure of Escherichia coli heat-stable enterotoxin b by nuclear
RT   magnetic resonance and circular dichroism.";
RL   Protein Sci. 4:1718-1729(1995).
CC   -!- FUNCTION: Toxin which activates the particulate form of guanylate
CC       cyclase and increases cyclic GMP levels within the host intestinal
CC       epithelial cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; M35729; AAA23989.1; -; Genomic_DNA.
DR   EMBL; M35586; AAA24655.1; -; Genomic_DNA.
DR   PIR; A33065; A33065.
DR   RefSeq; WP_000739296.1; NZ_UGEZ01000004.1.
DR   PDB; 1EHS; NMR; -; A=24-71.
DR   PDBsum; 1EHS; -.
DR   AlphaFoldDB; P22542; -.
DR   SMR; P22542; -.
DR   KEGG; ag:AAA23989; -.
DR   EvolutionaryTrace; P22542; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.10.10; -; 1.
DR   InterPro; IPR015160; STb_secrete.
DR   InterPro; IPR036479; STb_sf.
DR   Pfam; PF09075; STb_secrete; 1.
DR   SUPFAM; SSF57007; SSF57007; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Enterotoxin; Secreted; Signal; Toxin;
KW   Virulence.
FT   SIGNAL          1..23
FT   CHAIN           24..71
FT                   /note="Heat-stable enterotoxin II"
FT                   /id="PRO_0000035132"
FT   DISULFID        33..71
FT   DISULFID        44..59
FT   HELIX           33..45
FT                   /evidence="ECO:0007829|PDB:1EHS"
FT   STRAND          48..55
FT                   /evidence="ECO:0007829|PDB:1EHS"
FT   TURN            58..62
FT                   /evidence="ECO:0007829|PDB:1EHS"
FT   HELIX           63..66
FT                   /evidence="ECO:0007829|PDB:1EHS"
FT   TURN            67..69
FT                   /evidence="ECO:0007829|PDB:1EHS"
SQ   SEQUENCE   71 AA;  7642 MW;  D7D1B6EDF5347DE1 CRC64;
     MKKNIAFLLA SMFVFSIATN AYASTQSNKK DLCEHYRQIA KESCKKGFLG VRDGTAGACF
     GAQIMVAAKG C