ID   HSTN_VIBCL              Reviewed;          78 AA.
AC   P0A4M3; P04429;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Heat-stable enterotoxin ST;
DE   AltName: Full=Non O1-ST;
DE   AltName: Full=Non-agglutinating cholera vibrios ST;
DE            Short=NAG-ST;
DE   Flags: Precursor;
GN   Name=stn;
OS   Vibrio cholerae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRT36;
RX   PubMed=2205577; DOI=10.1128/iai.58.10.3325-3329.1990;
RA   Ogawa A., Kato J., Watanabe H., Nair B.G., Takeda T.;
RT   "Cloning and nucleotide sequence of a heat-stable enterotoxin gene from
RT   Vibrio cholerae non-O1 isolated from a patient with traveler's diarrhea.";
RL   Infect. Immun. 58:3325-3329(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 62-78.
RC   STRAIN=Serovar non-O1;
RX   PubMed=4065341; DOI=10.1016/0014-5793(85)80163-0;
RA   Takao T., Shimonishi Y., Kobayashi M., Nishimura O., Arita M., Takeda T.,
RA   Honda T., Miwatani T.;
RT   "Amino acid sequence of heat-stable enterotoxin produced by Vibrio cholerae
RT   non-01.";
RL   FEBS Lett. 193:250-254(1985).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heat-stable enterotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; M85198; AAA64889.1; -; Genomic_DNA.
DR   PIR; A41469; QHVC1.
DR   AlphaFoldDB; P0A4M3; -.
DR   SMR; P0A4M3; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019806; Heat-stable_enterotox_CS.
DR   InterPro; IPR001489; Heat-stable_enterotox_STa.
DR   Pfam; PF02048; Enterotoxin_ST; 1.
DR   PROSITE; PS00273; ENTEROTOXIN_H_STABLE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Enterotoxin; Secreted; Signal;
KW   Toxin; Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..61
FT                   /evidence="ECO:0000269|PubMed:4065341"
FT                   /id="PRO_0000035135"
FT   PEPTIDE         62..78
FT                   /note="Heat-stable enterotoxin ST"
FT                   /id="PRO_0000035136"
FT   DISULFID        64..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..76
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8830 MW;  EED385B298D0964F CRC64;
     MRNLFIALML LFSSIAFSQT VENNKKTVQQ PQQIESKVNI KKLSENEECP FIKQVDENGN
     LIDCCEICCN PACFGCLN