ID   HSTO_VIBCL              Reviewed;          78 AA.
AC   Q07425;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Heat-stable enterotoxin STO;
DE   AltName: Full=O1-ST;
DE   Flags: Precursor;
GN   Name=sto;
OS   Vibrio cholerae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=El Tor Inaba GP156 / Serotype O1;
RX   PubMed=8246823; DOI=10.1111/j.1348-0421.1993.tb01683.x;
RA   Ogawa A., Takeda T.;
RT   "The gene encoding the heat-stable enterotoxin of Vibrio cholerae is
RT   flanked by 123-base pair direct repeats.";
RL   Microbiol. Immunol. 37:607-616(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heat-stable enterotoxin family.
CC       {ECO:0000305}.
CC   -!- CAUTION: This toxin is only expressed in some vibrio strains. Most
CC       serotype-O1 strains do not express this toxin. {ECO:0000305}.
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DR   EMBL; L03220; AAA16516.1; -; Unassigned_DNA.
DR   EMBL; M97591; AAA27561.1; -; Genomic_DNA.
DR   RefSeq; WP_000792785.1; NZ_QXWD01000053.1.
DR   AlphaFoldDB; Q07425; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019806; Heat-stable_enterotox_CS.
DR   InterPro; IPR001489; Heat-stable_enterotox_STa.
DR   Pfam; PF02048; Enterotoxin_ST; 1.
DR   PROSITE; PS00273; ENTEROTOXIN_H_STABLE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Enterotoxin; Secreted; Signal; Toxin; Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..61
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035133"
FT   PEPTIDE         62..78
FT                   /note="Heat-stable enterotoxin STO"
FT                   /id="PRO_0000035134"
FT   DISULFID        64..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..76
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8742 MW;  6A6F9FB287EFA786 CRC64;
     MKNLFIALML LFSSIALSQT VENDTKTVQQ PQQIESKVNI KKLSENEECP FIKQVDENGN
     LIDCCEICCN PACFGCLN