ID   HSTX2_HAESL             Reviewed;          47 AA.
AC   P0DUG5;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   07-APR-2021, sequence version 1.
DT   25-MAY-2022, entry version 3.
DE   RecName: Full=Peptide HSTX-II {ECO:0000303|PubMed:29559913};
DE   Flags: Precursor;
OS   Haemadipsa sylvestris (Indian leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Hirudinida; Hirudiniformes; Haemadipsidae; Haemadipsa.
OX   NCBI_TaxID=13555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=29559913; DOI=10.3389/fphar.2018.00186;
RA   Wang G., Long C., Liu W., Xu C., Zhang M., Li Q., Lu Q., Meng P., Li D.,
RA   Rong M., Sun Z., Luo X., Lai R.;
RT   "Novel sodium channel inhibitor from leeches.";
RL   Front. Pharmacol. 9:186-186(2018).
CC   -!- FUNCTION: Leech salivary gland peptide with unknown function.
CC       {ECO:0000250|UniProtKB:A0A2L1DGG0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A0A2L1DGG0}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands. Highly expressed in
CC       the head, body and tail with a 2-3-fold higher expression in the head.
CC       {ECO:0000250|UniProtKB:A0A2L1DGG0}.
CC   -!- MISCELLANEOUS: Does not show effect on voltage-gated calcium channels,
CC       potassium channels, and tetrodotoxin-sensitive sodium channels. Does
CC       not show activity on Nav1.7/SCN9A, and shows very weak activity on
CC       cation channel TRPA1. {ECO:0000250|UniProtKB:A0A2L1DGG0}.
CC   -!- SIMILARITY: Belongs to the annelide toxin family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DUG5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Amidation; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..27
FT                   /evidence="ECO:0000250|UniProtKB:A0A2L1DGG0"
FT                   /id="PRO_0000452216"
FT   PEPTIDE         28..46
FT                   /note="Peptide HSTX-II"
FT                   /evidence="ECO:0000250|UniProtKB:A0A2L1DGG0"
FT                   /id="PRO_0000452217"
FT   MOD_RES         46
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250|UniProtKB:A0A2L1DGG0"
FT   DISULFID        26..37
FT                   /evidence="ECO:0000250|UniProtKB:A0A2L1DGG0"
FT   DISULFID        32..42
FT                   /evidence="ECO:0000250|UniProtKB:A0A2L1DGG0"
SQ   SEQUENCE   47 AA;  5015 MW;  4D8E6F7BECDD1436 CRC64;
     MKTLLVFLLL AILVAVFIGN AQVEACKNHT DCLSGICLKG FCMPAFG