ID   HST_YERKR               Reviewed;          66 AA.
AC   P31518;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Heat-stable enterotoxin;
DE   Flags: Precursor;
GN   Name=yst;
OS   Yersinia kristensenii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=28152;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IP490 / Serotype O:12,25;
RA   Ibrahim A., Liesack W., Stackebrandt E.;
RL   Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Toxin which activates the particulate form of guanylate
CC       cyclase and increases cyclic GMP levels within the host intestinal
CC       epithelial cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heat-stable enterotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; X69218; CAA49152.1; -; Genomic_DNA.
DR   PIR; S31652; S31652.
DR   RefSeq; WP_071841716.1; NZ_CWJK01000002.1.
DR   AlphaFoldDB; P31518; -.
DR   OrthoDB; 2174112at2; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019806; Heat-stable_enterotox_CS.
DR   InterPro; IPR001489; Heat-stable_enterotox_STa.
DR   Pfam; PF02048; Enterotoxin_ST; 1.
DR   PROSITE; PS00273; ENTEROTOXIN_H_STABLE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Enterotoxin; Secreted; Signal; Toxin; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..50
FT                   /id="PRO_0000035142"
FT   PEPTIDE         51..66
FT                   /note="Heat-stable enterotoxin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035143"
FT   DISULFID        54..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..66
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   66 AA;  7068 MW;  27BE7006675CC075 CRC64;
     MKKIVFVLVL MLSSFGTFGQ ETASRQFGDA FSTPIAAEVN KKACDTELPP SDWCCEVCCN
     PACAGC