ID   HSV2_KLULA              Reviewed;         339 AA.
AC   Q6CN23;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=SVP1-like protein 2;
GN   Name=HSV2; OrderedLocusNames=KLLA0E15972g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in mitochondrial or peroxisomal functions and amino
CC       acid signaling pathways. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Note=Vesicular and vacuolar. {ECO:0000250}.
CC   -!- DOMAIN: May contain a beta-propeller domain involved in specific
CC       binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the
CC       association of the protein to the membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PROPPIN family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99753.1; -; Genomic_DNA.
DR   RefSeq; XP_454666.1; XM_454666.1.
DR   PDB; 4AV8; X-ray; 3.35 A; A=1-339.
DR   PDB; 4AV9; X-ray; 3.00 A; A=1-339.
DR   PDB; 4EXV; X-ray; 3.00 A; A=1-339.
DR   PDB; 4V16; X-ray; 2.80 A; A=1-256, A=275-339.
DR   PDBsum; 4AV8; -.
DR   PDBsum; 4AV9; -.
DR   PDBsum; 4EXV; -.
DR   PDBsum; 4V16; -.
DR   AlphaFoldDB; Q6CN23; -.
DR   SMR; Q6CN23; -.
DR   STRING; 28985.XP_454666.1; -.
DR   EnsemblFungi; CAG99753; CAG99753; KLLA0_E15885g.
DR   GeneID; 2894192; -.
DR   KEGG; kla:KLLA0_E15885g; -.
DR   eggNOG; KOG2111; Eukaryota.
DR   HOGENOM; CLU_025895_0_1_1; -.
DR   InParanoid; Q6CN23; -.
DR   OMA; EEITHNS; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasmic vesicle; Membrane; Protein transport;
KW   Reference proteome; Repeat; Transport; Vacuole; WD repeat.
FT   CHAIN           1..339
FT                   /note="SVP1-like protein 2"
FT                   /id="PRO_0000051029"
FT   REPEAT          177..217
FT                   /note="WD 1"
FT   REPEAT          222..261
FT                   /note="WD 2"
FT   STRAND          19..22
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          26..32
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          34..41
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   TURN            42..45
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          46..52
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          56..61
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          65..72
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   TURN            73..76
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          77..82
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   TURN            83..86
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          87..93
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          98..103
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          105..112
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          115..122
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          127..133
FT                   /evidence="ECO:0007829|PDB:4AV9"
FT   STRAND          138..141
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          144..148
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          150..152
FT                   /evidence="ECO:0007829|PDB:4AV9"
FT   STRAND          155..160
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          163..165
FT                   /evidence="ECO:0007829|PDB:4EXV"
FT   STRAND          173..176
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          182..187
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          189..200
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          202..208
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   TURN            209..211
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          214..219
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          227..232
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          236..243
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   TURN            244..246
FT                   /evidence="ECO:0007829|PDB:4EXV"
FT   STRAND          247..252
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   HELIX           256..260
FT                   /evidence="ECO:0007829|PDB:4EXV"
FT   STRAND          279..283
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          294..307
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   TURN            308..311
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          312..321
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   TURN            322..325
FT                   /evidence="ECO:0007829|PDB:4V16"
FT   STRAND          326..336
FT                   /evidence="ECO:0007829|PDB:4V16"
SQ   SEQUENCE   339 AA;  39167 MW;  01257B224618FB81 CRC64;
     MLTRNPIVPE NHVSNPIVDY EFNQDQSCLI VSTPKSFDIY NVHPLKRIMS QEMPDAGTIR
     MLHRTNYIAF VSTKKELLHI WDDVKKQDIT RVKLDAAVKD LFLSREFIVV SQGDVISIFK
     FGNPWNKITE DIKFGGVCEF ANGLLVYSNE FNLGQIHVTR LQTDAEQVVG KGVLVKAHAN
     PVKMVRLNRK GDMVATCSQD GTLIRVFQTD NGVLVREFRR GLDRTSIIDM RWSPDGSKLA
     VVSDKWTLHV FEVFNDAENK RHVLKDWINI KYFQSEWSIC NFKLKVSKGS NDCKIAWISD
     TGLVIVWPNR RLADTFKLNY NDDEHVWWLQ LNQRNEIPL