ID   HSV2_YARLI              Reviewed;         359 AA.
AC   Q6CEI9;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=SVP1-like protein 2;
GN   Name=HSV2; OrderedLocusNames=YALI0B15290g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in mitochondrial or peroxisomal functions and amino
CC       acid signaling pathways. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Note=Vesicular and vacuolar. {ECO:0000250}.
CC   -!- DOMAIN: May contain a beta-propeller domain involved in specific
CC       binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the
CC       association of the protein to the membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PROPPIN family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG83174.1; -; Genomic_DNA.
DR   RefSeq; XP_500923.1; XM_500923.1.
DR   AlphaFoldDB; Q6CEI9; -.
DR   SMR; Q6CEI9; -.
DR   STRING; 4952.CAG83174; -.
DR   EnsemblFungi; CAG83174; CAG83174; YALI0_B15290g.
DR   GeneID; 2907330; -.
DR   KEGG; yli:YALI0B15290g; -.
DR   VEuPathDB; FungiDB:YALI0_B15290g; -.
DR   HOGENOM; CLU_025895_2_2_1; -.
DR   InParanoid; Q6CEI9; -.
DR   OMA; MGTTNYL; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0044804; P:autophagy of nucleus; IBA:GO_Central.
DR   GO; GO:0006497; P:protein lipidation; IBA:GO_Central.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Membrane; Protein transport; Reference proteome;
KW   Repeat; Transport; Vacuole; WD repeat.
FT   CHAIN           1..359
FT                   /note="SVP1-like protein 2"
FT                   /id="PRO_0000051033"
FT   REPEAT          186..225
FT                   /note="WD 1"
FT   REPEAT          231..270
FT                   /note="WD 2"
SQ   SEQUENCE   359 AA;  39141 MW;  1D5838FABE20E2D0 CRC64;
     MRTPDAHVIA SMEDQPILNA AFNQDSACFA ICHNRGFRVY VTDPMDLRVQ REFDDGGIGV
     IQMLHRTNYL AVVGGGSNPK FPQNKLVIWD DLKSKPALSL EFLSPVLNVL LSRTKIVVVL
     QNKVHVYAFS SPPSRISTTD TADNPHGIAA FSGDTVVFPS RTPGQIQVVD LSQEGQARNL
     VSIIRAHKSP VRCVTLSADG SVVASCSDNG TLVRLHSTSN TALLHEFRRG LDRAVVYNMA
     FSPSGSRLAV LSDKNTMHVF DTSASASGAA GAANRRHVLG KVPLLPSYFS GEWSFVSARV
     QGQHGVLGWS SETSVVVVWI SEARWEKYVI VEKKPVEGSG KDQPGCELVR EAWRAFKDL