HSYA_TOBAC
ID HSYA_TOBAC Reviewed; 165 AA.
AC Q93WP8;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=Hydroxyproline-rich systemin A;
DE Contains:
DE RecName: Full=HypSysA I;
DE AltName: Full=TobHypSysA I;
DE Contains:
DE RecName: Full=HypSysA II;
DE AltName: Full=TobHypSysA II;
DE Flags: Precursor;
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000312|EMBL:AAK52096.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 36-53 AND 144-161,
RP FUNCTION, TISSUE SPECIFICITY, MASS SPECTROMETRY, HYDROXYLATION AT PRO-42;
RP PRO-43; PRO-45; PRO-49; PRO-50; PRO-150; PRO-151 AND PRO-153, AND
RP GLYCOSYLATION.
RX PubMed=11459063; DOI=10.1038/35081107;
RA Pearce G., Moura D.S., Stratmann J., Ryan C.A.;
RT "Production of multiple plant hormones from a single polyprotein
RT precursor.";
RL Nature 411:817-820(2001).
RN [2] {ECO:0000305}
RP REVIEW ON FUNCTION.
RX PubMed=12949264; DOI=10.1073/pnas.1934788100;
RA Ryan C.A., Pearce G.;
RT "Systemins: a functionally defined family of peptide signals that regulate
RT defensive genes in Solanaceae species.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:14577-14580(2003).
CC -!- FUNCTION: Activates a lipid-based signal transduction pathway in which
CC linolenic acid is converted to jasmonic acid, a potent activator of
CC defense gene transcription, including proteinase inhibitors.
CC {ECO:0000269|PubMed:11459063}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in leaves. {ECO:0000269|PubMed:11459063}.
CC -!- INDUCTION: By methyl jasmonate in leaves.
CC {ECO:0000269|PubMed:11459063}.
CC -!- PTM: O-glycosylated; contains pentose side chains.
CC {ECO:0000269|PubMed:11459063}.
CC -!- MASS SPECTROMETRY: [HypSysA I]: Mass=3060; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11459063};
CC -!- MASS SPECTROMETRY: [HypSysA II]: Mass=2784; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11459063};
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DR EMBL; AY033148; AAK52096.1; -; mRNA.
DR AlphaFoldDB; Q93WP8; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Hormone; Hydroxylation;
KW Plant defense; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..35
FT /evidence="ECO:0000255, ECO:0000269|PubMed:11459063"
FT /id="PRO_0000021456"
FT PEPTIDE 36..53
FT /note="HypSysA I"
FT /evidence="ECO:0000269|PubMed:11459063"
FT /id="PRO_0000021457"
FT PROPEP 54..143
FT /evidence="ECO:0000269|PubMed:11459063"
FT /id="PRO_0000021458"
FT PEPTIDE 144..161
FT /note="HypSysA II"
FT /evidence="ECO:0000269|PubMed:11459063"
FT /id="PRO_0000021459"
FT PROPEP 162..165
FT /evidence="ECO:0000269|PubMed:11459063"
FT /id="PRO_0000021460"
FT REGION 33..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT MOD_RES 43
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT MOD_RES 45
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT MOD_RES 49
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT MOD_RES 50
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT MOD_RES 150
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT MOD_RES 151
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT MOD_RES 153
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11459063"
FT CARBOHYD 42
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 43
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 50
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 150
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
SQ SEQUENCE 165 AA; 18344 MW; 34B995686271BF90 CRC64;
MRVLFLIYLI LSPFGAEART LLENHEGLNV GSGYGRGANL PPPSPASSPP SKEVSNSVSP
TRTDEKTSEN TELVMTTIAQ GENINQLFSF PTSADNYYQL ASFKKLFISY LLPVSYVWNL
IGSSSFDHDL VDIFDSKSDE RYWNRKPLSP PSPKPADGQR PLHSY
