HT1_TRYVI
ID HT1_TRYVI Reviewed; 543 AA.
AC Q27115;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Glucose transporter HT1;
GN Name=HT1;
OS Trypanosoma vivax (Duttonella vivax).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX NCBI_TaxID=5699;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8620878; DOI=10.1111/j.1432-1033.1996.0234n.x;
RA Waitumbi J.N., Tetaud E., Baltz T.;
RT "Glucose uptake in Trypanosoma vivax and molecular characterization of its
RT transporter gene.";
RL Eur. J. Biochem. 237:234-239(1996).
CC -!- FUNCTION: Facilitative glucose transporter. Binds D-fructose and
CC cytochalasin-B, but not D-galactose.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; L47540; AAB03513.1; -; Genomic_DNA.
DR PIR; S65462; S65462.
DR AlphaFoldDB; Q27115; -.
DR SMR; Q27115; -.
DR VEuPathDB; TriTrypDB:TvY486_1008330; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR PANTHER; PTHR23503; PTHR23503; 2.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..543
FT /note="Glucose transporter HT1"
FT /id="PRO_0000050386"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..337
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..400
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..436
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..470
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 492..543
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 543 AA; 57195 MW; 88D491F4EBE3CA3A CRC64;
MPEYPTEDTN ASGKTSGSSP DDHTDDNAPS FFSCENLCIV QVPVSTGSLN GFSIGFVAVY
MHLYEIFSGC SALESSGACS GNSKCTWIPN NSTCVWKDCN GAAGATTCKD GSGYNSLESG
LFACSMIVGS MIGSIFAGKF LSKFGLKMSF IVSGVLGIVG SALIHVATRG STLWVMCVGR
FLMGLVLGLV CVASPMYVNE NAHPKYRKTI GVLFQVFTTF GIMFAALLGL AIVKTPGHDK
ASGLLWRMQV FCSVSTALSA LLLVLGLVVR KSKTSFAGGV DSAGEGVLDP NEYSVRQMLG
PLAVGAVTAG TLQLTGINAV MNYAPEIMRN IGMDPMEGNS AVMSWNFVTA LVAIPLVSRF
TMRQLFLACS FMASCACLIM CGIPVYPGVA SVDNRNIVAT VGIAVFIAAF EFGVGSCFFV
LAQDLFPRSF RPTGSSFVVM AQFIFNIMIN LLYPITVEAI SGGKGKSPEK GQSVSFIIFG
IIGIICFVLQ LRYLTPWEDG QGTSTSPTAR CNAPTSPNNG EGEPATADMS PVEMSTPKHS
GAA
