ID   HTD2_SCHPO              Reviewed;         300 AA.
AC   Q9Y814;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Hydroxyacyl-thioester dehydratase type 2, mitochondrial;
DE            EC=4.2.1.-;
DE   AltName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase;
GN   Name=htd2; ORFNames=SPBC1105.15c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in
CC       fatty acid biosynthesis. Required for respiratory growth and for normal
CC       mitochondrial morphology (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HTD2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB50978.1; -; Genomic_DNA.
DR   PIR; T39292; T39292.
DR   RefSeq; NP_596471.1; NM_001022390.2.
DR   AlphaFoldDB; Q9Y814; -.
DR   BioGRID; 276296; 1.
DR   STRING; 4896.SPBC1105.15c.1; -.
DR   MaxQB; Q9Y814; -.
DR   PaxDb; Q9Y814; -.
DR   EnsemblFungi; SPBC1105.15c.1; SPBC1105.15c.1:pep; SPBC1105.15c.
DR   PomBase; SPBC1105.15c; htd2.
DR   VEuPathDB; FungiDB:SPBC1105.15c; -.
DR   eggNOG; ENOG502S5QU; Eukaryota.
DR   HOGENOM; CLU_028690_3_0_1; -.
DR   InParanoid; Q9Y814; -.
DR   OMA; WDIEERR; -.
DR   PhylomeDB; Q9Y814; -.
DR   PRO; PR:Q9Y814; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005739; C:mitochondrion; ISS:PomBase.
DR   GO; GO:0019171; F:3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; ISS:PomBase.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; ISS:PomBase.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   Lyase; Mitochondrion; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..300
FT                   /note="Hydroxyacyl-thioester dehydratase type 2,
FT                   mitochondrial"
FT                   /id="PRO_0000351436"
SQ   SEQUENCE   300 AA;  34675 MW;  43156BCED33355C6 CRC64;
     MSAKVVLKDF LSQAPIDKLK ATLSGHLPVS CITMDAKITS LQPGYHFLFF SLASPESNLN
     SDGYESLYSP KPNNPFSFKR RIWLHGVLRF HRPLHLFQTS ECHELIQEES VKSPSITKEV
     EACLPKSSFL TKPTSEKQTK HVYIRRKIYD SQHQLCIEED RTLAYLNRQE LAIPKTLRSK
     SIPQHSWVFT PTPIMVFRYS ALMFNAHMIH WNATYATKSE NYPNLVLPGP LLVTSMLEYF
     RSVYPQMSKN MKRFEFRLLS PAFVNQPLRI CISETGNLWI DRFTTDLDPP SLIARGRVYT